NSL1
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Official Full Name
NSL1, MIND kinetochore complex component, homolog (S. cerevisiae) -
Overview
This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
NSL1;NSL1, MIND kinetochore complex component, homolog (S. cerevisiae);C1orf48, chromosome 1 open reading frame 48;kinetochore-associated protein NSL1 homolog;DC8;DKFZP566O1646;MIS14;4833432M17Rik;AI451597;C1orf48;DC31;Gm105;Gm984;Kinetochore associated protein NSL1 homolog
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NSL1-260H | Recombinant Human NSL1, MIS12 kinetochore complex component, His-tagged | E.coli | Human | His | 1-281 a.a. |
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| NSL1-3138Z | Recombinant Zebrafish NSL1 | Mammalian Cells | Zebrafish | His |
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| NSL1-3438C | Recombinant Chicken NSL1 | Mammalian Cells | Chicken | His |
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| NSL1-442HCL | Recombinant Human NSL1 lysate | HEK293 | Human | Non |
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Involved Pathway
NSL1 involved in several pathways and played different roles in them. We selected most pathways NSL1 participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,M Phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with NSL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell Cycle, Mitotic | MAPRE1B,SMC4,CDK4,CENPC1,NIPBL,SPDL1,CEP72,NUP50,GORASP1,SPC25 |
| RHO GTPases Activate Formins | DIAPH1,KNTC1,NDEL1B,SPDL1,RANGAP1B,FMNL2,RHOC,SKA1,ZWILCH,RCC2 |
| Mitotic Anaphase | ZWILCH,CENPQ,MIS12,NUDC,NUF2,B9D2,PANE1,AHCTF1,ZWINT,CENPC1 |
| RHO GTPase Effectors | WIPF3,ABI1,ABI1A,NOXO1,RCC2,RHPN2,RTKN,DIAPH1,KTN1,FMNL1 |
| Cell cycle | SFN,HUS1,CDK11A,ORC4,CDKN1BB,CCND1,ORC3L,YWHABB,ENSA,YWHAH |
| Mitotic Metaphase and Anaphase | CENPK,SPC24,CENPQ,WAPAL,B9D2,AHCTF1,PDS5A,NDEL1B,SKA1,CENPN |
| Mitotic Prometaphase | NDEL1A,SMC2,ZWINT,NCAPG,NUF2,INCENP,SMC4,CENPH,KNTC1,WAPAL |
| M Phase | STAG1,NDEL1A,PDS5B,ENSA,ITGB3BP,CLIP1,NIPBLA,ARPP19,CENPA,RCC2 |
Protein Function
NSL1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NSL1 itself. We selected most functions NSL1 had, and list some proteins which have the same functions with NSL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DSN1,LCE3E,NKX2-5,IGFL1,CEP68,JAM2,ILF2,PKM2,HDC,ARID1A |
Interacting Protein
NSL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NSL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NSL1.
MIS12;ZWINT;Casc5;Mis12;LRRK2;Bub1;BUB1;Ndc80;Bub1b;G6PC;CBX5;YWHAZ;CBX3;SPC24
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