NRXN2
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Official Full Name
neurexin 2 -
Overview
This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules;and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are;produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are;produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth;factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The;beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing;and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID:;11944992). -
Synonyms
NRXN2;neurexin 2;FLJ40892;KIAA0921;neurexin-2-beta;neurexin II;neurexin II-beta;neurexin-2-alpha;neurexin II-alpha
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NRXN2-055H |
Active Recombinant Human Neurexin 2 Fc-tagged
|
CHO | Human | Fc | 1-1566 a.a. |
|
| NRXN2-4087R | Recombinant Rat NRXN2 Protein | Mammalian Cell | Rat | His |
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| NRXN2-18H | Recombinant Human NRXN2 protein, His-tagged | HEK293 | Human | His | Gln34-Thr1427 |
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| NRXN2-3748R | Recombinant Rat NRXN2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
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| NRXN2-3748R-B | Recombinant Rat NRXN2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| RFL19967HF | Recombinant Full Length Human Neurexin-2-Beta(Nrxn2) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (51-666) |
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Involved Pathway
NRXN2 involved in several pathways and played different roles in them. We selected most pathways NRXN2 participated on our site, such as Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with NRXN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | CNTN2,MADCAM1,HLA-DRB5,NADL1.2,LRRC4C,CLDN11,VCAN,NEO1,MHC2A,OCLNA |
Protein Function
NRXN2 has several biochemical functions, for example, calcium channel regulator activity,cell adhesion molecule binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NRXN2 itself. We selected most functions NRXN2 had, and list some proteins which have the same functions with NRXN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cell adhesion molecule binding | VCAM1,PKP3,PVRL3,PVRL1,FGFR1,ITGB3,NLGN2,PTPRD,POSTNB,GRIN2A |
| metal ion binding | BMPR1B,ZNHIT3,TGFBR1B,ATP1A1A.2,USP2,ZBTB5,CYP2V1,CREB5,THAP6,FHL3B |
| neuroligin family protein binding | NRXN3,NRXN1,DLG4 |
| calcium channel regulator activity | GRM7,NRXN3,TSPAN13B,GRM2,NPY2R,SRI,TSPAN13A,STIM2,STIM1A,SGK2A |
| transmembrane signaling receptor activity | CD247,DCC,CELSR3,CD300C,KLRD1,SEMA4D,GHRHRL,KLRB1,NRXN1,TLR5 |
Interacting Protein
NRXN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NRXN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NRXN2.
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References
- Dachtler, J; Glasper, J; et al. Deletion of alpha-neurexin II results in autism-related behaviors in mice. TRANSLATIONAL PSYCHIATRY 4:-(2014).
- Traunmuller, L; Bornmann, C; et al. Alternative Splicing Coupled Nonsense-Mediated Decay Generates Neuronal Cell Type-Specific Expression of SLM Proteins. JOURNAL OF NEUROSCIENCE 34:16755-16761(2014).
