NRP2
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Official Full Name
neuropilin 2 -
Overview
Vascular Endothelial Growth Factor (VEGF) is a potent mitogen for vascular endothelial cells. It significantly influences vascular permeability and is a strong angiogenic protein. VEGF probably also plays a role in neovasularization under physiological conditions. A potent synergism between VEGF and bFGF in the induction of angiogenesis has been observed. Due to its influences on vascular permeability, VEGF may be involved in altering blood-brain-barrier functions under normal and pathological conditions. -
Synonyms
NRP2;neuropilin 2;neuropilin-2;VEGF165R2;neuropilin-2b(0);neuropilin-2a(17);neuropilin-2a(22);receptor for VEGF165 and semaphorins class3;vascular endothelial cell growth factor 165 receptor 2;NP2;NPN2;PRO2714;MGC126574
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- HEK293
- Mammalian cells
- Human Cell
- Mammalian Cell
- E.coli
- HEK293T
- His
- Fc
- His&T7
- His&GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
NRP2 involved in several pathways and played different roles in them. We selected most pathways NRP2 participated on our site, such as Axon guidance,Developmental Biology,L1CAM interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with NRP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| L1CAM interactions | CHL1,CNTN6,CD24,KIF4,EZRA,KCNQ3,RANBP9,CNTN1,KIF4A,SCN4A |
| Signal Transduction | LINGO1,DLK1,CCNT2B,ASH2L,CIT,RIT2,VIP2,GRAP,SAGB,RNF43 |
| Signaling by VEGF | NRP2A,SHB,DSCAMA,NRP2B,AXL,JUPA |
| Developmental Biology | SHB,CDK19,MED10,SCN2B,EFNB2A,CACNG3,ARPC4,NR2F2,EPHB3A,EVL |
| Neurophilin interactions with VEGF and VEGFR | NRP2A,NRP2B,NRP1A |
| Axon guidance | KLB,SPRED3,EFNA1,PAK3,EPHA4A,DUSP6,SEMA3D,EFNB3,KDR,UNC5A |
Protein Function
NRP2 has several biochemical functions, for example, cytokine binding,growth factor binding,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NRP2 itself. We selected most functions NRP2 had, and list some proteins which have the same functions with NRP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heparin binding | HDGF,WISP1A,OVALX,FGF7,FGFBP3,OGN,CFH,CRISPLD2,FGF14,PCOLCE |
| cytokine binding | KIT,CSF1R,KITA,IL31RA,ELANE,IFNGR1,TNFRSF11A,CXCR4,KITB,CHRD |
| receptor activity | SLC40A1,FKBP3,EXTL3,ANXA2R,CALCR,CD4,RTN4RL2,PAQR4,NLGN3B,CNTNAP1 |
| vascular endothelial growth factor-activated receptor activity | NRP2A,PDGFRA,NRP1A,NRP1,FLT1,FLT3,FLT4,NRP2B,KDR,NRP1B |
| growth factor binding | IL6ST,FLT4,TEK,ERBB3,KDR,RHBDF1,IGFBP2B,BMPR2,GHR,LTBP4 |
| semaphorin receptor activity | NRP2A,PLXNC1,PLXNB2,PLXNB2A,PLXNA3,PLXND1,PLXNA1B,Plxna2,NRP1,PLXNA1 |
| metal ion binding | FAM164A,HNRNPA0L,FHL1A,NKD2A,AARS,AOX4,POLA1,ZFP90,ZNF671,LHX2A |
Interacting Protein
NRP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NRP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NRP2.
Resources
Research Area
VEGF Receptors and Regulators on Endothelial CellsVEGF Family
Semaphorins, Plexin Receptors, and Related Molecules
VEGF Receptor
Related Services
Related Products
References
- Gogineni, A; Caunt, M; et al. Inhibition of VEGF-C Modulates Distal Lymphatic Remodeling and Secondary Metastasis. PLOS ONE 8:-(2013).
- Susarla, R; Gonzalez, AM; et al. Expression of receptors for VEGFs on normal human thyroid follicular cells and their role in follicle formation. JOURNAL OF CELLULAR PHYSIOLOGY 227:1992-2002(2012).
