NRF1
-
Official Full Name
nuclear respiratory factor 1 -
Overview
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression;of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis,;and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of;neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized.;Additional variants encoding different protein isoforms have been described but they have not been fully;characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and;for nuclear factor (erythroid-derived 2)-like 1 which has an official symbol of NFE2L1. -
Synonyms
NRF1;nuclear respiratory factor 1;alpha palindromic binding protein;ALPHA PAL;EWG;NRF-1;alpha palindromic-binding protein;ALPHA-PAL
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Mouse
- Schizosaccharomyces pombe
- HEK293
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293T
- Yeast
- Mammalian cells
- Mamanlian cells
- E.coli expression system
- Myc&DDK
- His
- Non
- His&MBP
- His&Fc&Avi
- His&SUMO
- Flag
Involved Pathway
NRF1 involved in several pathways and played different roles in them. We selected most pathways NRF1 participated on our site, such as Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with NRF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Huntingtons disease | NDUFAB1,UQCRB,NDUFA11,HDAC2,ATP5E,COX6B1,HTT,Atp5g2,NDUFS8,POLR2B |
Protein Function
NRF1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,core promoter sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NRF1 itself. We selected most functions NRF1 had, and list some proteins which have the same functions with NRF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | PLSCR1,GABPA,FIGLA,EGR1,NKX2,TFAP2B,MEF2A,NDN,STK16,HEYL |
| core promoter sequence-specific DNA binding | MEOX1,SP1,SOX9,THRAP3,ZFP932,ESR1,RORA,C1orf51,ZFP750,NR1D2 |
| protein binding | PTMA,NUP62CL,PAQR5,CAMK2D,ATP2A2,FAM168A,ECHS1,NEBL,CD164,KCNE1L |
| protein homodimerization activity | EIF2AK1,FOXP2,CD226,AIMP1,RXRB,ATPIF1A,DMRT1,FZD1,CCDC88A,HPRT1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | MYBL2,PAX8,MSX2,KCNIP3,CARF,ARID3B,RELA,RFX2,SNAI3,FLI1 |
Interacting Protein
NRF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NRF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NRF1.
SP4;TRAF2;FHL2;POGZ;PB1;PB1;sph
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References
- Zhao, WW; Ma, GX; et al. Lipopolysaccharide induced LOX-1 expression via TLR4/MyD88/ROS activated p38MAPK-NF-kappa B pathway. VASCULAR PHARMACOLOGY 63:162-172(2014).
- Sotgia, F; Whitaker-Menezes, D; et al. Mitochondria "fuel" breast cancer metabolism Fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells. CELL CYCLE 11:4390-4401(2012).
