NR3C2
-
Official Full Name
nuclear receptor subfamily 3, group C, member 2 -
Overview
This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] -
Synonyms
NR3C2;nuclear receptor subfamily 3, group C, member 2;MR;MCR;MLR;NR3C2VIT;mineralocorticoid receptor;aldosterone receptor;mineralocorticoid receptor 1;mineralocorticoid receptor delta
Recombinant Proteins
- Human
- Chicken
- Rat
- Zebrafish
- E.coli
- Sf9 Insect Cell
- HEK293
- Mammalian Cell
- Wheat Germ
- His&GST
- His
- GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
NR3C2 involved in several pathways and played different roles in them. We selected most pathways NR3C2 participated on our site, such as Aldosterone-regulated sodium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR3C2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aldosterone-regulated sodium reabsorption | PRKCG,MAPK1,PIK3R2,PRKCA,FXYD4,SGK1,INS1,PIK3CB,PIK3R5,ATP1A2 |
Protein Function
NR3C2 has several biochemical functions, for example, protein binding,sequence-specific DNA binding,steroid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR3C2 itself. We selected most functions NR3C2 had, and list some proteins which have the same functions with NR3C2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | SIX1A,NFATC2,SOX3,ZFP322A,POU3F1,POU5F3,UBN2B,STAT5A,FOXD1,ZNF19 |
| sequence-specific DNA binding | POU3F2A,PRDM5,PRRXL1,DLX2B,CENPB,FOXQ2,TBX5A,MAFGA,HOXA2B,POU2F1B |
| steroid binding | PGRMC2,PAQR5B,ESRRGB,CYP21A2,PAQR7A,PAQR7,PAQR5,ESR2A,ESRRGA,PGR |
| steroid hormone receptor activity | RXRA,NR2F6B,NR2F1,PPARDB,RARG,RARAB,NR4A2B,RARB,NR5A1A,RARGA |
| zinc ion binding | RXRGA,TOPORS,NANOS1,ALPP,CRIP2,RNF144AA,FBLIM1,ZFPL1,Shh,ZDHHC8B |
| protein binding | NUP54,SIVA1,MEPE,MRPL44,KAT2A,ORC4L,CAPN2,KIF4A,DPYSL2,UBE2D2 |
Interacting Protein
NR3C2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR3C2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR3C2.
HSP90AB1;RXRA;ACSL1;RABAC1
Resources
Related Services
Related Products
References
- Kolla, V; Robertson, NM; et al. Identification of a mineralocorticoid/glucocorticoid response element in the human Na/K ATPase alpha 1 gene promoter. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 266:5-14(1999).
