NR1D2

  • Official Full Name

    nuclear receptor subfamily 1, group D, member 2

  • Overview

    This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described.

  • Synonyms

    NR1D2;nuclear receptor subfamily 1, group D, member 2;nuclear receptor subfamily 1 group D member 2;BD73;EAR 1r;Hs.37288;HZF2;RVR;EAR-1R;NR1D2_HUMAN;Orphan nuclear hormone receptor BD73;Rev erb beta;Rev-erb-beta;REVB;REVERBB;V-erbA-related protein 1-related;OTTHUMP00000208397;rev-erba-alpha-related receptor;nuclear receptor Rev-ErbA beta variant 1;nuclear receptor Rev-ErbA beta var

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Mouse
  • Sf9 Insect Cell
  • E.coli
  • Mammalian Cell
  • Sf21 Insect Cell
  • HEK293
  • HEK293T
  • Wheat Germ
  • In Vitro Cell Free System
  • Non
  • His&GST
  • His
  • Myc&DDK
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
NRID2-1150H Active Recombinant Human Nuclear R eceptor Subfamily 1, Group D, Member 2 Sf9 Insect Cell Human Non
Nr1d2-1082R Recombinant Rat Nr1d2 protein, His & GST-tagged E.coli Rat His&GST Lys249~Pro578
NR1D2-30452TH Recombinant Human NR1D2 Human Non Full L. 1-408 a.a.
NR1D2-6758C Recombinant Chicken NR1D2 Mammalian Cell Chicken His
NR1D2-8488H Recombinant Human NR1D2, His-tagged Sf21 Insect Cell Human His
NR1D2-3721HCL Recombinant Human NR1D2 293 Cell Lysate HEK293 Human Non
NR1D2-2532H Recombinant Human NR1D2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
Nr1d2-4484M Recombinant Mouse Nr1d2 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
NR1D2-6068H Recombinant Human NR1D2 Protein, GST-tagged Wheat Germ Human GST
NR1D2-6693HF Recombinant Full Length Human NR1D2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 579 amino acids

    Involved Pathway

    NR1D2 involved in several pathways and played different roles in them. We selected most pathways NR1D2 participated on our site, such as Diurnally regulated genes with circadian orthologs,Gene Expression,Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR1D2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Nuclear Receptor transcription pathway NRBF2,NR6A1A,NR2C2AP,NRBF2B,NR2F6A,NR1I2,RARAA,ESRRG,ESRRGA,NR5A1
    Diurnally regulated genes with circadian orthologs CEBPB,RBPMS,EIF4G2,AZIN1,KLF9,GFRA1,DAZAP2,UCP3,SF3A3,CRY1
    Gene Expression ZNF443,ZNF556,WARS2,NR2E3,EHMT2,TFB2M,ZNF747,ZNF468,COX14,SF3B4
    Nuclear Receptors NR2E1,NR2F1A,RARGA,NR4A2A,RORAA,RARG,NR1D2B,VDRB,NR1I2,NR2F1
    Generic Transcription Pathway ZNF256,COX6C,NR2F6,ZNF37A,ZKSCAN3,RRAGA,RARAB,NR1D2A,ZNF671,ZNF550

    Protein Function

    NR1D2 has several biochemical functions, for example, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding,core promoter sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR1D2 itself. We selected most functions NR1D2 had, and list some proteins which have the same functions with NR1D2. You can find most of the proteins on our site.

    Function Related Protein
    core promoter sequence-specific DNA binding ZFHX3,H2AFY,ZNF750,REST,ESR1,CRY1,MTA1,CHD2,PPARG,TP53
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding NR4A1,NR1H4,ESRRB,RORB,NR2E3,NR1I3,NR5A1,STAT3,PPARAB,NR2F1B
    steroid hormone receptor activity NR2F6,RORAA,NR5A2,NR5A1B,RXRA,VDR,HNF4G,ESRRB,RXRGB,RXRB
    zinc ion binding HNF4G,MID1,APOBEC4,ZNF385C,G2E3,POLR2I,ZDHHC16,PGLYRP6,FHL5,RASGRP1
    protein binding GAGE8,ARF4,SMCO4,ZNF473,CDK4,MC2R,PLEKHF2,TRIM21,INPP4B,APOA2

    Interacting Protein

    NR1D2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR1D2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR1D2.

    Clock;PRMT6;BHLHE40;CSNK2A2;RORC;Cry1;Csnk1e

    Resources

    References

    • Lazado, CC; Kumaratunga, HPS; et al. In vitro and ex vivo models indicate that the molecular clock in fast skeletal muscle of Atlantic cod is not autonomous. MOLECULAR BIOLOGY REPORTS 41:6679-6689(2014).
    • Lazado, CC; Kumaratunga, HPS; et al. Daily Rhythmicity of Clock Gene Transcripts in Atlantic Cod Fast Skeletal Muscle. PLOS ONE 9:-(2014).

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