NPY
-
Official Full Name
neuropeptide Y -
Overview
Neuropeptide Y (NPY) is a 36-amino acid neuropeptide that acts as a neurotransmitter in the brain and in the autonomic nervous system of humans; slight variations of the peptide are found in many other animals. In the autonomic system it is mainly produced by neurons of the sympathetic nervous system and serves as a strong vasoconstrictor and also causes growth of fat tissue. In the brain it is produced in various locations including the hypothalamus, and is thought to have several functions, including: increasing food intake and storage of energy as fat, reducing anxiety and stress, reducing pain perception, affecting the circadian rhythm, reducing voluntary alcohol intake, lowering blood pressure and controlling epileptic seizures. -
Synonyms
PYY4;pro-neuropeptide Y
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Rat
- Zebrafish
- E.coli
- HEK293
- Wheat Germ
- Mammalian Cell
- In Vitro Cell Free System
- Mammalian cells
- GST
- His
- Fc
- Non
- His&GST
- His&Fc&Avi
- SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NPY-1350H | Recombinant Human NPY, GST-tagged | E.coli | Human | GST | 1-97aa | |
| NPY-233H | Recombinant Human NPY protein, His-tagged | E.coli | Human | His |
|
|
| NPY-262H | Recombinant Human NPY Protein, Fc-tagged | HEK293 | Human | Fc | 29-64 a.a. |
|
| NPY-29247TH | Recombinant Human NPY | Wheat Germ | Human | Non | 69 amino acids |
|
| NPY-29655TH | Recombinant Human NPY | Wheat Germ | Human | Non | 97 amino acids |
|
| NPY-3086R | Recombinant Rhesus monkey NPY Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
|
|
| NPY-7022C | Recombinant Chicken NPY | Mammalian Cell | Chicken | His |
|
|
| Npy-7870R | Recombinant Rat Npy protein, His & GST-tagged | E.coli | Rat | His&GST | Pro31~Trp98 |
|
| NPY-8700Z | Recombinant Zebrafish NPY | Mammalian Cell | Zebrafish | His |
|
|
| NPY-3726HCL | Recombinant Human NPY 293 Cell Lysate | HEK293 | Human | Non |
|
|
| NPY-1267H | Recombinant Human NPY Protein, His-tagged | E.coli | Human | His |
|
|
| NPY-2905R | Recombinant Rhesus Macaque NPY Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
|
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| NPY-2905R-B | Recombinant Rhesus Macaque NPY Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
|
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| NPY-344HF | Active Recombinant Full Length Human NPY Protein | In Vitro Cell Free System | Human | Full L. 97 amino acids |
|
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| NPY-4717H | Recombinant Human NPY protein, His-tagged | HEK293 | Human | Fc | Met1-Gln43 |
|
| NPY-4718H | Recombinant Human NPY Protein (Tyr29-Trp97), N-His tagged | Mammalian cells | Human | His | Tyr29-Trp97 |
|
| NPY-4719H | Recombinant Human NPY Protein (Tyr29-Trp97), N-SUMO tagged | E.coli | Human | SUMO | Tyr29-Trp97 |
|
| NPY-6052H | Recombinant Human NPY Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| NPY-6654HF | Recombinant Full Length Human NPY Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 97 amino acids |
|
Involved Pathway
NPY involved in several pathways and played different roles in them. We selected most pathways NPY participated on our site, such as cAMP signaling pathway,Adipocytokine signaling pathway,Regulation of lipolysis in adipocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPY were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adipocytokine signaling pathway | ADIPOQ,TNFRSF1B,ACACB,G6PC3,NFKBIAA,ACSL4A,POMC,ACSL3A,MTOR,SOCS3 |
| Regulation of lipolysis in adipocytes | TSHB,AKT2,LOC100328615,PRKACA,GNAI1,GNAI3,ABHD5,PTGS1,Adcy4,IRS2 |
| cAMP signaling pathway | GNAS,HCAR2,GNAI2,CNGA4,HCAR3,RRAS,MAPK8,RAC1,MLLT4,PIK3CA |
| Alcoholism | GNB4,PRKACA,HIST2H2AA2,GNG3,NTRK2,HIST3H2BB-PS,BDNF,CRH,BRAF,HIST4H4 |
Protein Function
NPY has several biochemical functions, for example, G-protein coupled receptor activity,calcium channel regulator activity,neuropeptide Y receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPY itself. We selected most functions NPY had, and list some proteins which have the same functions with NPY. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| neuropeptide Y receptor binding | PYYA |
| neuropeptide hormone activity | GAL,NPPA,ADCYAP1,PENK,GRP,VIP,CALCB,POMCA,PNOC,NPFF |
| G-protein coupled receptor activity | VMN1R45,GPR34A,S1PR1,GPR32,OPN1SW,HCRTR1,GPR25,ADRB3B,V1RA8,GPR22 |
| calcium channel regulator activity | Crisp4,NRXN3,SGK3,NRXN2,SGK2B,GRM3,HPCAL4,GRM2A,SGK2A,GRM2 |
| receptor binding | FGF6B,ARPP19,ICOSLG,LYN,NRXN1,RASA1,CX3CL1,SLC27A2,HRG,SNX17 |
Interacting Protein
NPY has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPY here. Most of them are supplied by our site. Hope this information will be useful for your research of NPY.
DPP4;FAP;UBQLN1;BAG6;ATP12A;NR1H2;Ccdc64;Rab6b
Resources
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References
- Lei, MM; Wu, SQ; et al. Creating leptin-like biofunctions by active immunization against chicken leptin receptor in growing chickens. DOMESTIC ANIMAL ENDOCRINOLOGY 50:55-64(2015).
- Czeh, B; Varga, ZKK; et al. Chronic Stress Reduces the Number of GABAergic Interneurons in the Adult Rat Hippocampus, Dorsal-Ventral and Region-Specific Differences. HIPPOCAMPUS 25:393-405(2015).
