NME6
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Official Full Name
non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase) -
Overview
Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of;gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates;(Mehus et al., 1999 (PubMed 10453732)). -
Synonyms
NME6;non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase);nucleoside diphosphate kinase 6;IPIA ALPHA;NM23 H6;NDP kinase 6;inhibitor of p53-induced apoptosis-alpha;NDK 6;NM23-H6;IPIA-ALPHA
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Zebrafish
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&T7
- Myc&DDK
- His&Fc&Avi
Involved Pathway
NME6 involved in several pathways and played different roles in them. We selected most pathways NME6 participated on our site, such as Biosynthesis of antibiotics,CMP phosphorylation,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NME6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| CMP phosphorylation | CMPK2 |
| Pyrimidine metabolism | POLR3K,CMPK,POLR1A,TYMS,RRM2B,NT5C3A,CANT1B,POLR2J2,POLE4,UPP1 |
| Metabolic pathways | COX7B2,GLCE,ALG5,PIGO,PIP5K1BA,GNSA,FUT7,CHIA.2,GNPDA1,MBOAT1 |
| Biosynthesis of antibiotics | LDHAL6A,GALM,AKR1A1,SDSL,DAO1,ACAA2,DLD,GPR19,DLST,PAICS |
| UTP and CTP de novo biosynthesis | CMPK2 |
| Purine metabolism | POLE3,PRUNE,POLR1E,NME7,POLR1C,ADKB,FHIT,NT5C3B,POLD1,CANT1 |
Protein Function
NME6 has several biochemical functions, for example, ATP binding,metal ion binding,nucleoside diphosphate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NME6 itself. We selected most functions NME6 had, and list some proteins which have the same functions with NME6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | TGFBR2,ZC4H2,TEC,NR2F6A,NUDT14,GNAZ,TKTL1,NEURL1AB,COQ7,RPS27.1 |
| nucleoside diphosphate kinase activity | AK8,NME4,NME2A,CMPK1,AK4,NME9,NME3,AK9,CMPK2,NME2 |
| ATP binding | KIF22,NSFB,UBA6,CLK2A,UBE2S,LRRK1,GM4922,RAD51,DDR1,PHKG2 |
Interacting Protein
NME6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NME6 here. Most of them are supplied by our site. Hope this information will be useful for your research of NME6.
SSSCA1;WBSCR16
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References
- Haglund, S; Almer, S; et al. Gene Expression and Thiopurine Metabolite Profiling in Inflammatory Bowel Disease - Novel Clues to Drug Targets and Disease Mechanisms?. PLOS ONE 8:-(2013).
- Wang, CH; Ma, NH; et al. A shRNA Functional Screen Reveals Nme6 and Nme7 Are Crucial for Embryonic Stem Cell Renewal. STEM CELLS 30:2199-2211(2012).
