NLRP8
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Official Full Name
NLR family, pyrin domain containing 8 -
Overview
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs,;such as NALP8, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a;NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636),;also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD).;NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in;multiprotein complexes called inflammasomes (Tschopp et al., 2003 (PubMed 12563287)). -
Synonyms
NLRP8;NLR family, pyrin domain containing 8;NACHT, leucine rich repeat and PYD containing 8 , NALP8;NACHT, LRR and PYD domains-containing protein 8;CLR19.2;NOD16;nucleotide binding oligomerization domain;leucine rich repeat and pyrin domain containing 8;PAN4;NACHT, leucine rich repeat and PYD containing 8;NACHT, LRR and PYD containing protein 8;NALP8;NALP8_HUMAN;Nucleotide-binding oligomerization domain protein 16;Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 8;PYRIN and NACHT-containing protein 4
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
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| NLRP8-3051R | Recombinant Rhesus monkey NLRP8 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| NLRP8-1007H | Recombinant Human NLRP8 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| NLRP8-2870R | Recombinant Rhesus Macaque NLRP8 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| NLRP8-2870R-B | Recombinant Rhesus Macaque NLRP8 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
NLRP8 involved in several pathways and played different roles in them. We selected most pathways NLRP8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NLRP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
NLRP8 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by NLRP8 itself. We selected most functions NLRP8 had, and list some proteins which have the same functions with NLRP8. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
NLRP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NLRP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of NLRP8.
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References
- Krishnaswamy, JK; Singh, A; et al. Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:3056-3061(2015).
- Suzuki, S; Mimuro, H; et al. Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:E4254-E4263(2014).
