NKX3-1
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Official Full Name
NK3 homeobox 1 -
Overview
The Nkx3.1 gene is an androgen regulated prostate-specific homeobox gene, located on chromosome 8p21. In mice the homologue Nkx3.1 is exclusively expressed in prostate epithelium. In humans, Nkx3.1 expression is also restricted to the prostate. Many data show that Nkx3.1 expression is highly, but not exclusively, specific for the prostate. -
Synonyms
NKX3-1;NK3 homeobox 1;NK homeobox (Drosophila), family 3, A , NK3 transcription factor related, locus 1 (Drosophila) , NKX3A;homeobox protein Nkx-3.1;BAPX2;NKX3.1;NK homeobox, family 3, A;homeobox protein NK-3 homolog A;NK3 transcription factor homolog A;NK3 transcription factor related, locus 1;NKX3;NKX3A
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cell
- Wheat Germ
- E. coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- N-Twin strep and C-His&Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
NKX3-1 involved in several pathways and played different roles in them. We selected most pathways NKX3-1 participated on our site, such as Pathways in cancer,Prostate cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with NKX3-1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Prostate Cancer | SMARCC2,NFKBIA,LEF1,TP53,ERBB2,TGFA,IGF1,PIK3CD,CREB3L1,ARAF |
| Pathways in cancer | RXRG,WNT9B,GNA12,Casp3,STAT5B,FGF5,FZD8,MMP2,LAMA1,TPR |
Protein Function
NKX3-1 has several biochemical functions, for example, DNA binding,MADS box domain binding,androgen receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NKX3-1 itself. We selected most functions NKX3-1 had, and list some proteins which have the same functions with NKX3-1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | HOXC6A,HES1,SPI1B,FOXC1A,TP53,POU3F3,SOX17,NR1H3,DMRT3,NKX2.2B |
| DNA binding | TFDP1B,ZBED6,POLR2F,NABP2,PAX7B,LIN54,NFYA,LCOR,CEBPB,AKAP8L |
| androgen receptor activity | NR1I3,NKX3,Ar |
| MADS box domain binding | NKX3 |
| contributes_to transcription factor activity, RNA polymerase II core promoter sequence-specific | SRF |
| transcription regulatory region sequence-specific DNA binding | NR5A1A,NFE2L2B,MEF2CA,SIN3A,NFE2,MKL1,HIF1AL,EGR1,CRY2,GATA1 |
| transcription regulatory region DNA binding | CDK5RAP2,ZFP161,FOXA3,HNF4A,REST,RCOR1,FOXC1,BCL11AB,RREB1,TA |
| estrogen receptor activity | LEF1,GPR30,NKX3,ESR1,ESR2A,ESR2,ESR2B |
| transcription factor activity, sequence-specific DNA binding | KDM5A,ZNF23,MZF1,EGR1,NR5A5,RFXAP,HOXD3A,SIM1,ZSCAN4F,GTF2I |
Interacting Protein
NKX3-1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKX3-1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NKX3-1.
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References
- Mohanty, SK; Smith, SC; et al. Evaluation of Contemporary Prostate and Urothelial Lineage Biomarkers in a Consecutive Cohort of Poorly Differentiated Bladder Neck Carcinomas. AMERICAN JOURNAL OF CLINICAL PATHOLOGY 142:173-183(2014).
- Epstein, JI; Egevad, L; et al. Best Practices Recommendations in the Application of Immunohistochemistry in the Prostate Report From the International Society of Urologic Pathology Consensus Conference. AMERICAN JOURNAL OF SURGICAL PATHOLOGY 38:E6-E19(2014).
