NHLRC1
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Official Full Name
NHL repeat containing 1 -
Overview
The protein encoded by this gene is a single subunit E3 ubiquitin ligase. Laforin is polyubiquitinated by the encoded;protein. Defects in this intronless gene lead to an accumulation of laforin and onset of Lafora disease, also known as;progressive myoclonic epilepsy type 2 (EPM2). -
Synonyms
NHLRC1;NHL repeat containing 1;E3 ubiquitin-protein ligase NHLRC1;bA204B7.2;epilepsy;progressive myoclonus type 2B;EPM2B;malin;MGC119265;EPM2A;MGC119262;MGC119264;NHL repeat containing protein 1;NHL repeat-containing protein 1;NHLC1_HUMAN;NHLRC 1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NHLRC1-1291H | Recombinant Human NHLRC1, GST-tagged | E.coli | Human | GST | C-310aa | |
| NHLRC1-3984R | Recombinant Rat NHLRC1 Protein | Mammalian Cell | Rat | His |
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| NHLRC1-30H | Recombinant Human NHLRC1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| NHLRC1-3643R | Recombinant Rat NHLRC1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| NHLRC1-3643R-B | Recombinant Rat NHLRC1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
NHLRC1 involved in several pathways and played different roles in them. We selected most pathways NHLRC1 participated on our site, such as Glucose metabolism,Glycogen synthesis,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with NHLRC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glucose metabolism | SLC25A12,PYGMB,SLC25A1,SLC25A11,SLC25A1A,SLC25A10,GYG1A,GYG2,AGL,GYG1B |
| Glycogen synthesis | GYG1B,EPM2A,GYG1A |
| Metabolism of carbohydrates | PFKLB,SLC25A10,HAS1,SLC25A13,ST3GAL3A,SLC35B2,HS3ST6,CHP,SLC25A1A,EPM2A |
| Metabolism | NEU4,PLBD1,COQ7,AQP1A.1,TPTE,GCHFR,D2HGDH,ACSM1,SURF1,LYPLA1 |
| Ubiquitin mediated proteolysis | ITCH,BIRC7,NEDD4L,UBOX5,UBE2D1B,CDC23,PIAS4B,BIRC3,CUL3,HUWE1 |
Protein Function
NHLRC1 has several biochemical functions, for example, ligase activity,protein binding,ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NHLRC1 itself. We selected most functions NHLRC1 had, and list some proteins which have the same functions with NHLRC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase activity | UBE2R2,MED27,RNF24,RBX1,UBE2C,SYVN1,STUB1,UBE3C,MED31,ITCHA |
| ligase activity | PIAS3,TTLL11,TRIP12,SYVN1,MARCH1,PARK2,SH3RF1,MARCH5,RING1,MUL1 |
| protein binding | STUB1,LRDD,ZSCAN12,FGF2,TGOLN2,VAV2,USP33,SRC,CDH15,PRAP1 |
| ubiquitin-protein transferase activity | BIRC5,TRIM68,ANAPC4,TRAF7,BRCA1,FBXO22,RNF5,RNF144B,MYCBP2,RNF6 |
| zinc ion binding | NRAP,LIMS3L,RP9,FHL3B,ZBTB32,ZDHHC24,TRIM5,LMX1BA,ZDHHC19,UBR3 |
Interacting Protein
NHLRC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NHLRC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NHLRC1.
EPM2A;Epm2a;HSP90AB1
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References
- Brackmann, FA; Kiefer, A; et al. Rapidly Progressive Phenotype of Lafora Disease Associated With a Novel NHLRC1 Mutation. PEDIATRIC NEUROLOGY 44:475-477(2011).
- Smith, JA; Lovley, DR; et al. Outer Cell Surface Components Essential for Fe(III) Oxide Reduction by Geobacter metallireducens. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 79:901-907(2013).
