NGFRAP1
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Official Full Name
nerve growth factor receptor (TNFRSF16) associated protein 1 -
Overview
The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR. Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Coexpression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed. -
Synonyms
NGFRAP1;nerve growth factor receptor (TNFRSF16) associated protein 1;protein BEX3;Bex;BEX3;brain expressed;X linked 3;DXS6984E;HGR74;NADE;brain expressed, X-linked 3;brain-expressed X-linked protein 3;ovarian granulosa cell protein (13kD);p75NTR-associated cell death executor;ovarian granulosa cell 13.0 kDa protein HGR74;nerve growth factor receptor-associated protein 1
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Rat
- Mammalian Cell
- E.coli
- HEK293
- Yeast
- His
- Non
- His&GST
- His&Fc&Avi
- GST
Involved Pathway
NGFRAP1 involved in several pathways and played different roles in them. We selected most pathways NGFRAP1 participated on our site, such as Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NGFRAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neurotrophin signaling pathway | RPS6KA2,CALM1,MAP3K3,PLCG1,TRP53,YWHAE,MAPK3,RAF1,MAP2K7,IRS1 |
Protein Function
NGFRAP1 has several biochemical functions, for example, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NGFRAP1 itself. We selected most functions NGFRAP1 had, and list some proteins which have the same functions with NGFRAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | VRK2,MAP3K13,AKAP5,E2F1,ATF2,GATA6,KIF13B,GCET2,TUBB3,DUSP3 |
Interacting Protein
NGFRAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NGFRAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NGFRAP1.
CCDC116;FSD2;NECAB2;GOLGA8F;GOLGA8DP;USHBP1;CTNNBL1
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