NFKBIE
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Official Full Name
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -
Overview
The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. -
Synonyms
NFKBIE;nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon;NF-kappa-B inhibitor epsilon;IKBE;ikB-E;ikB-epsilon;NF-kappa-BIE;ikappaBepsilon;I-kappa-B-epsilon
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E. coli
- E.coli
- Mammalian Cell
- HEK293
- His
- GST
- His&T7
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NFKBIE-001H |
Recombinant Human NFKB inhibitor epsilon Protein, His tagged
|
E. coli | Human | His | 141-500 aa | |
| NFKBIE-1283H | Recombinant Human NFKBIE, GST-tagged | E.coli | Human | GST | C-term-361aa | |
| NFKBIE-10627M | Recombinant Mouse NFKBIE Protein | Mammalian Cell | Mouse | His |
|
|
| Nfkbie-1301M | Recombinant Mouse Nfkbie protein, His & T7-tagged | E.coli | Mouse | His&T7 | Ala115~Phe350 |
|
| NFKBIE-232H | Recombinant Human NFKBIE protein, His-tagged | E.coli | Human | His |
|
|
| NFKBIE-28876TH | Recombinant Human NFKBIE, His-tagged | E.coli | Human | His | 319-500 a.a. |
|
| NFKBIE-5017Z | Recombinant Zebrafish NFKBIE | Mammalian Cell | Zebrafish | His |
|
|
| NFKBIE-4697H | Recombinant Human NFKBIE Protein (Arg207-Pro440), N-His tagged | E.coli | Human | His | Arg207-Pro440 |
|
| NFKBIE-6042M | Recombinant Mouse NFKBIE Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| NFKBIE-6042M-B | Recombinant Mouse NFKBIE Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
NFKBIE involved in several pathways and played different roles in them. We selected most pathways NFKBIE participated on our site, such as T cell receptor signaling pathway,B cell receptor signaling pathway,Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFKBIE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adipocytokine signaling pathway | ACSL1B,POMCA,RXRG,MAPK8,AKT2L,RXRBA,PRKCQ,NFKBIA,AKT2,CAMKK1 |
| Epstein-Barr virus infection | TRAF3,MAP3K14,RBPJ,MAPK12,POLR2H,EIF2AK3,TBK1,TNFAIP3,TAB1,HSPB2 |
| B Cell Receptor Signaling Pathway | MAP4K1,PLEKHA2,CD22,LYN,BCL2L11,CD72,INPPL1,CD79B,ARPC4,GRB2 |
| Neurotrophin signaling pathway | MAPK7,PRDM4,MAP2K5,MAP3K5,SHC2,PIK3CD,TRAF6,CAMK4,IRAK4,MAP2K7 |
| T cell receptor signaling pathway | PPP3CC,MAPK12,PPP3CA,SHB,SLA1,PAK2,NFKB1,PPP3CB,AKT1,NCK1 |
Protein Function
NFKBIE has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFKBIE itself. We selected most functions NFKBIE had, and list some proteins which have the same functions with NFKBIE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TRAM1,DLG1,CDPF1,PRMT1,TRPM6,THOC5,BABAM1,ODF2,ZNF404,UQCRB |
Interacting Protein
NFKBIE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFKBIE here. Most of them are supplied by our site. Hope this information will be useful for your research of NFKBIE.
PPP6R2;PPP6R1;C1QBP;ANKHD1;RELA;NFKB2;ebi-359405;PPP6C;ANKRD28;CHUK;ANKRD17;BAG2;TUBB4A
Resources
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References
- Suzuki, T; Ikari, K; et al. PADI4 and HLA-DRB1 Are Genetic Risks for Radiographic Progression in RA Patients, Independent of ACPA Status: Results from the IORRA Cohort Study. PLOS ONE 8:-(2013).
