NFATC1
-
Official Full Name
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 -
Overview
The NFAT (nuclear factor of activated T cells) family of proteins consists of NFAT1 (NFATc2 or NFATp), NFAT2 (NFATc1 or NFATc), NFAT3 (NFATc4), and NFAT4 (NFATc3 or NFATx). All members of this family are transcription factors with a Rel homology domain an -
Synonyms
NFATC1;nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1;nuclear factor of activated T-cells, cytoplasmic 1;NF ATC;NFAT2;NFATc;NF-ATc1;NFAT transcription complex cytosolic component;NF-ATC;MGC138448
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Sf9 Insect Cell
- HEK293
- HEK293T
- His
- Non
- GST
- Flag
- Myc&DDK
Involved Pathway
NFATC1 involved in several pathways and played different roles in them. We selected most pathways NFATC1 participated on our site, such as MAPK signaling pathway,cGMP-PKG signaling pathway,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFATC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | WNT9B,PPP3R2,SMAD4,RHOAA,CAMK2D2,WNT4,CTNNBIP1,PRKACAB,WNT7A,ROCK2A |
| Natural killer cell mediated cytotoxicity | KIR2DL4,SH2D1B,FCGR4,RAET1E,TNFRSF10A,RAET1D,KIR2DS2,PRKCA,VAV3,SHC4 |
| cAMP signaling pathway | CALML3,CALM2,PIK3CD,ATP2A2,MAPK8,FXYD2,GRIN2B,CAMK2A,RRAS2,GNAI3 |
| T cell receptor signaling pathway | CD8B,PLCG1,PAK2,PAK7,CD3E,PIK3R2,MAPK11,CBLB,SHB,VAV1 |
| Osteoclast differentiation | SFPI1,MAPK10,NCF1,PPARG,CYLD,PPP3CC,GAB2,GRB2,MAPK8,cgr2b |
| Inflammatory bowel disease (IBD) | HLA-DPA1,SMAD2,IL5,HLA-DQA1,TBX21,TNF,IL4,HLA-DPB1,IFNG,IL18R1 |
| MAPK signaling pathway | FGF9,KRAS,CD14,PAK2B,FGF2,ELK1,MKNK2B,MAP2K4,STMN1,PPM1NA |
| B Cell Receptor Signaling Pathway | RAC2,ARPC4,VAV1,ITPR2,MAP4K1,CMTM3,RAC3,MAPK4,MAP2K1,Cd79a |
| Oxytocin signaling pathway | CACNG6,PLA2G4A,PPP3CC,CAMK2B,CCND1,MEF2C,MAPK7,PIK3CG,MAP2K2,MYLK2 |
Protein Function
NFATC1 has several biochemical functions, for example, FK506 binding,RNA polymerase II distal enhancer sequence-specific DNA binding,RNA polymerase II transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFATC1 itself. We selected most functions NFATC1 had, and list some proteins which have the same functions with NFATC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| mitogen-activated protein kinase p38 binding | TAB1,RPS6KA4,SPAG9,PRMT1 |
| protein binding | PDP1,CHMP4A,EIF2B3,NETO2,PAIP2,CPSF6,GINS4,SIRPG,CLDN18,TBXAS1 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | MYOG,SPI1,HNF1B,MEIS1,PAX3,NR5A1,TLE4,NKX2-5,FOXP3,ATF2 |
| RNA polymerase II distal enhancer sequence-specific DNA binding | SIX3,TAL1,H2AFZ,FLI1,ARID3B,SFPQ,BACH2,NONO,HOXB5,RUVBL2 |
| transcription factor activity, sequence-specific DNA binding | FOSL1A,NTNG1,NFIL3-3,CNOT8,RARAB,NFIL3-2,OTX1B,NR1D4B,LHX8A,PAX6 |
| RNA polymerase II transcription factor binding | GATA1,GSK3B,GATA5,ATF4,MIXL1,TAL1,GATA6,PITX2,TOX2,ZFPM1 |
| transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding | NFE2L2,SPI1,NFE2L1,CUX1,REL,ARID3B,POU4F1,TARDBP,FOXH1,HCFC1 |
| FK506 binding | FKBP11,FKBP6,FKBP3,FKBP1AA,FKBP4,FKBP10,FKBP10B,TTC9B,FKBP14,FKBP1AB |
Interacting Protein
NFATC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFATC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFATC1.
OGT;Ppp3cb;JAK3;icam1_human_nfkb-intron_dna-probe;YWHAZ;icam1_human_gene;il2_human_gene
NFATC1 Related Signal Pathway
Resources
Research Area
Transcription Regulators in VSMCTranscription Factors in the Akt Pathway
Epithelial Stem Cell Transcription Factors
T Cell Cytokine Signaling
C-type Lectin Receptors
T Follicular Helper (Tfh) Cells
Related Services
Related Products
References
- Wang, HC; Jiang, WP; et al. Fibroblasts isolated from a keratocystic odontogenic tumor promote osteoclastogenesis in vitro via interaction with epithelial cells. ORAL DISEASES 21:170-177(2015).
- Pletinckx, K; Vaeth, M; et al. Immature dendritic cells convert anergic nonregulatory T cells into Foxp3(-)IL-10(+) regulatory T cells by engaging CD28 and CTLA-4. EUROPEAN JOURNAL OF IMMUNOLOGY 45:480-491(2015).
