NDUFV1

  • Official Full Name

    NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa

  • Overview

    The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinsons disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

  • Synonyms

    NDUFV1;NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa;NADH dehydrogenase (ubiquinone) flavoprotein 1 (51kD);NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial;CI 51K;complex I 51kDa subunit;NADH dehydrogenase [ubiquinone] flavoprotein 1;mitochondrial;CI 51kD;CI-51kD;Complex I 51kD;Complex I-51kD;FLJ59059;NADH dehydrogenase (ubiquinone) flavoprotein 1;NADH dehydrogenase flavoprotein 1;NADH ubiquinone oxidoreductase 51 kDa subunit;NADH ubiquinone oxidoreductase;NADH-ubiquinone oxidoreductase 51 kDa subunit;NDUFV 1;NDUV1_HUMAN;UQOR1;OTTHUMP00000232178;OTTHUMP00000232181;OTTHUMP00000232183;OTTHUMP00000232187;complex I 51 kda subunit;complex I, mitochondrial respiratory chain;NADH-ubiquinone oxidoredu;CI-51K;CI51KD

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • Chicken
  • Cynomolgus
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293T
  • HEK293
  • GST
  • His
  • Non
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
NDUFV1-1243H Recombinant Human NDUFV1, GST-tagged E.coli Human GST C-term-350aa
NDUFV1-10548M Recombinant Mouse NDUFV1 Protein Mammalian Cell Mouse His
NDUFV1-1086Z Recombinant Zebrafish NDUFV1 Mammalian Cell Zebrafish His
NDUFV1-29479TH Recombinant Human NDUFV1 Wheat Germ Human Non 100 amino acids
NDUFV1-3224C Recombinant Chicken NDUFV1 Mammalian Cell Chicken His
NDUFV1-741C Recombinant Cynomolgus NDUFV1 Protein, His-tagged Mammalian Cell Cynomolgus His
NDUFV1-1180HCL Recombinant Human NDUFV1 cell lysate Human Non
NDUFV1-2770H Recombinant Human NDUFV1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
Ndufv1-4348M Recombinant Mouse Ndufv1 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
NDUFV1-485C Recombinant Cynomolgus Monkey NDUFV1 Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus His&Fc&Avi
NDUFV1-485C-B Recombinant Cynomolgus Monkey NDUFV1 Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus
NDUFV1-5994M Recombinant Mouse NDUFV1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
NDUFV1-5994M-B Recombinant Mouse NDUFV1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    NDUFV1 involved in several pathways and played different roles in them. We selected most pathways NDUFV1 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFV1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alzheimers disease ATP2A1,APOE,NDUFV2,ATP5G3,SDHA,MAPK3,NDUFA1,RYR3,PPP3CB,COX6B1
    Huntingtons disease SLC25A4,NDUFB11,COX4I1,UQCR11,POLR2A,CREB3L1,POLR2J3,DNAHC8,NDUFB10,NDUFA12
    Parkinsons disease DRD1A,ATP5G1,SDHA,NDUFA2,NDUFB7,UBB,NDUFA3,ATP5E,VDAC2,COX7A2L
    Metabolic pathways ALDH9A1B,NDUFS8B,ASL2,GGT1,CYP51,FUT3,ISYNA1,MAPK1IP1L,GAMT,HOGA1
    Non-alcoholic fatty liver disease (NAFLD) NDUFA3,NDUFB3,NDUFS5,NDUFS7,UQCR10,PRKAA1,LEPR,IRS2,PKLR,AKT2
    Oxidative phosphorylation ATP6V0CA,NDUFS8,ATP4A,UQCRB,NDUFAB1,ATP5S,PPA2,COX7A3,ATP6V0A2,NDUFS4

    Protein Function

    NDUFV1 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding,contributes_to FMN binding,NAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFV1 itself. We selected most functions NDUFV1 had, and list some proteins which have the same functions with NDUFV1. You can find most of the proteins on our site.

    Function Related Protein
    NAD binding GAPDH,ME3,CYB5R3,HSD17B10,CTBP1,LDHA,AOX3,HSD3B5,AOX3L1,GRHPRB
    NADH dehydrogenase (ubiquinone) activity NDUFAB1,NDUFA9,NDUFA4,NDUFC1,NDUFB7,NDUFAF2,NDUFS6,NDUFB2,NDUFB4,NDUFS5
    contributes_to NADH dehydrogenase activity NDUFS2,NDUFS7,NDUFS8
    metal ion binding AGFG1,PKM,ZNF726,ZNF177,ATP11A,BMPR1B,PDE5A,ENPP4,PPP3CC,ZFP827
    4 iron, 4 sulfur cluster binding DDX11,NTHL1,NUBPL,IREB2,REV3L,POLE,NDUFS1,NFU1,DPYD,NUBP2

    Interacting Protein

    NDUFV1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFV1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFV1.

    NDUFA2;EWSR1;NDUFS8;NDUFS4;NDUFS5;NDUFS2;NDUFS6;NDUFS3;NDUFB4;MT-ND1;MT-ND5;NDUFV2;NDUFS1;HTT;OXCT1;NDUFV3

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