NDUFAF2
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Official Full Name
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2 -
Overview
NADH:ubiquinone oxidoreductase (complex I) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. This gene encodes a complex I assembly factor. Mutations in this gene cause progressive encephalopathy resulting from mitochondrial complex I deficiency. -
Synonyms
NDUFAF2;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2;NDUFA12 like , NDUFA12L;mimitin, mitochondrial;B17.2L;mimitin;MMTN;Myc induced mitochondrial protein;NDUFA12-like protein;Myc-induced mitochondrial protein;NDUFA12L;F
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NDUFAF2-1230H | Recombinant Human NDUFAF2, His-tagged | E.coli | Human | His | 1-169aa | |
| NDUFAF2-1008H | Recombinant Human NDUFAF2, His-tagged | E.coli | Human | His |
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| NDUFAF2-2978R | Recombinant Rhesus monkey NDUFAF2 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| NDUFAF2-30238TH | Recombinant Human NDUFAF2, His-tagged | E.coli | Human | His | 169 amino acids |
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| NDUFAF2-4251C | Recombinant Chicken NDUFAF2 | Mammalian Cell | Chicken | His |
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| NDUFAF2-6361Z | Recombinant Zebrafish NDUFAF2 | Mammalian Cell | Zebrafish | His |
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| NDUFAF2-946H | Recombinant Human NDUFAF2 | Mammalian Cell | Human | His |
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| NDUFAF2-436HCL | Recombinant Human NDUFAF2 lysate | HEK293 | Human | Non |
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| NDUFAF2-2797R | Recombinant Rhesus Macaque NDUFAF2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| NDUFAF2-2797R-B | Recombinant Rhesus Macaque NDUFAF2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| NDUFAF2-3600H | Recombinant Human NDUFAF2 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| NDUFAF2-3600H-B | Recombinant Human NDUFAF2 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| Ndufaf2-4336M | Recombinant Mouse Ndufaf2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| NDUFAF2-517H | Recombinant Human NDUFAF2 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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Involved Pathway
NDUFAF2 involved in several pathways and played different roles in them. We selected most pathways NDUFAF2 participated on our site, such as Metabolism,Respiratory electron transport,Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFAF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | CYGB1,TPMT.2,PFKLB,FAAH2,SLC5A4,NQO1,DHCR24,ETFA,AGL,CTRC |
| Respiratory electron transport | TACO1,COX18,FAM36A,C20orf7,COX11,COX14,NDUFAF6,NDUFAF5,TIMMDC1,SURF1 |
| Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | COX18,ATP5L,NDUFAF4,NDUFAF7,ETFA,UCP3,ETFB,SCO1,NDUFAF6,SLC25A14 |
| The citric acid (TCA) cycle and respiratory electron transport | C2orf56,FAM36A,SLC25A27,COX16,NDUFAF5,NDUFAF6,ETFDH,UCP2,SLC25A14,TACO1 |
| Validated targets of C-MYC transcriptional activation | DDX18,MYCT1,MTDH,HUWE1,IREB2,SERPINI1,PEG10,LIN28B,CDCA7,PDCD10 |
Protein Function
NDUFAF2 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFAF2 itself. We selected most functions NDUFAF2 had, and list some proteins which have the same functions with NDUFAF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADH dehydrogenase (ubiquinone) activity | NDUFAB1,NDUFB7,NDUFB9,NDUFA2,NDUFB4,NDUFS4,NDUFC1,NDUFA10,NDUFA13,NDUFS6 |
Interacting Protein
NDUFAF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFAF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFAF2.
OPTN;ATXN3;CHST15
Resources
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References
- Schlehe, JS; Journel, MSM; et al. The mitochondrial disease associated protein Ndufaf2 is dispensable for Complex-1 assembly but critical for the regulation of oxidative stress. NEUROBIOLOGY OF DISEASE 58:57-67(2013).
- Pereira, B; Videira, A; et al. Novel Insights into the Role of Neurospora crassa NDUFAF2, an Evolutionarily Conserved Mitochondrial Complex I Assembly Factor. MOLECULAR AND CELLULAR BIOLOGY 33:2623-2634(2013).
