NDP
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Official Full Name
Norrie disease (pseudoglioma) -
Overview
This gene encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix. Mutations in this gene result in Norrie disease and X-linked exudative vitreoretinopathy. -
Synonyms
NDP;Norrie disease (pseudoglioma);EVR2, exudative vitreoretinopathy 2 (X linked);norrin;EVR2;Exudative vitreoretinopathy 2 (X linked);FEVR;ND;NDP_HUMAN;Norrie disease protein;Norrin precursor;X linked exudative vitreoretinopathy 2 protein;X-linked exudative vitreoretinopathy 2 protein
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- Cynomolgus
- E.coli
- Mammalian Cell
- HEK293
- Non
- His
- His&Fc&Avi
Involved Pathway
NDP involved in several pathways and played different roles in them. We selected most pathways NDP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NDP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
NDP has several biochemical functions, for example, cytokine activity,frizzled binding,growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDP itself. We selected most functions NDP had, and list some proteins which have the same functions with NDP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | BMP5,VEGFB,IL6,PPBP,CTGF,KLK1B3,CSF1A,BMP1,BDNF,MIA |
| frizzled binding | WNT9A,WNT8A,WNT2B,LRP6,WNT7AA,BAMBI,DVL3A,WNT2BB,SFRP1,WNT10B |
| cytokine activity | BMP1,LFT1,IL20,IFNPHI4,IL28A,SP100,IFNA7,IL17A/F1,VSTM1,BMP3 |
| protein binding | CHIC2,LARP4B,MATN2,MNAT1,YIPF3,CLINT1,WBP1L,GNS,DCD,APAF1 |
| protein homodimerization activity | SLC22A1,NOS2,UGT1A1,MID1,ENO3,USH2A,NR0B2,APOA4,ANXA1,P2RX4 |
Interacting Protein
NDP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDP here. Most of them are supplied by our site. Hope this information will be useful for your research of NDP.
FZD4;PPP1CA;LRP5;TSPAN12
Resources
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References
- Botte, DAC; Noronha, IL; et al. Alpha-melanocyte stimulating hormone ameliorates disease activity in an induced murine lupus-like model. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 177:381-390(2014).
- Spak, J; Votruba, I; et al. Antiviral activity of tenofovir against Cauliflower mosaic virus and its metabolism in Brassica pekinensis plants. ANTIVIRAL RESEARCH 92:378-381(2011).
