NCF1
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Official Full Name
neutrophil cytosolic factor 1 -
Overview
The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a;multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with;chronic granulomatous disease. -
Synonyms
NCF1;neutrophil cytosolic factor 1;neutrophil cytosolic factor 1 (47kD, chronic granulomatous disease, autosomal 1);neutrophil cytosol factor 1;chronic granulomatous disease;autosomal 1;NADPH oxidase organizer 2;NCF1A;NOXO2;p47phox;SH3PXD1A;NCF-1;NCF-47K;p47-phox;nox organizer 2;nox-organizing protein 2;47 kDa neutrophil oxidase factor;neutrophil NADPH oxidase factor 1;SH3 and PX domain-containing protein 1A;47 kDa autosomal chronic granulomatous disease protein;neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1);FLJ79451
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- E.coli
- Mammalian Cell
- Human
- HEK293
- HEK293T
- Mammalian cells
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
- Flag
Involved Pathway
NCF1 involved in several pathways and played different roles in them. We selected most pathways NCF1 participated on our site, such as Chemokine signaling pathway,Phagosome,Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | CXCL16,IKBKG,CXCR5,SOS1,RAF1,PLCB1,CCL3L1,RHOA,Ccl12,VAV1 |
| Leukocyte transendothelial migration | PTK2B,GNAI2,MAPK13,THY1,RHOA,CLDN3,VAV3,RAP1A,MYL7,MLLT4 |
| Osteoclast differentiation | PIK3CD,NFKB1,MAP3K7,SOCS1,TGFBR2,PIK3CG,PIK3R5,SPI1,PIK3R2,IL1R1 |
| Phagosome | TLR4,HLA-DMB,CD14,ATP6AP1B,ATP6V1E1,FCGR2A,CTSSA,DYNC1LI2,MARCO,Cd209g |
| Fc gamma R-mediated phagocytosis | RPS6KB1,RPS6KB2,WASF2,WASF1,PRKCA,PIK3R2,cgr2b,LYN,PLD1,ARPC1A |
| Leishmaniasis | IL1B,NFKBIB,HLA-DQA1,HLA-DMB,HLA-DQB1,MAP3K7,FCGR1A,MAPK12,TAB2,H2-AB1 |
Protein Function
NCF1 has several biochemical functions, for example, SH3 domain binding,electron carrier activity,phosphatidylinositol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCF1 itself. We selected most functions NCF1 had, and list some proteins which have the same functions with NCF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| electron carrier activity | FDX1L,AOX1,NDUFV2,NDUFS1,GCDHA,ME1,TXNRD3,HAAO,NDUFS3,PHGDH |
| superoxide-generating NADPH oxidase activity | PAX2,NOX1,CYBB,SH3PXD2AA,NOX4,NOX3,NOX5 |
| protein binding | FOXO1,H2AFZ,HHLA3,PSMD5,VAC14,IQCB1,SUN2,KCNE2,ITSN2,ZNF212 |
| phosphatidylinositol-3,4-bisphosphate binding | PHLDA3,RS1,AKT1,FAM21C,DAPP1,PLEK,SESTD1,ZFYVE1,ANXA8,ADAP2 |
| phosphatidylinositol binding | NISCH,ING2,WDR35,SNX27,SNX15,SNX10A,ITPR2,PXK,TULP2,SNX10B |
| SH3 domain binding | PDCD6IP,SH3BP5B,INPP5D,SH3BP5L,ARHGAP31,DPYSL3,ZFP106,NOXA1,KHDRBS2,ITM2B |
Interacting Protein
NCF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCF1.
NCF2;CYBA;RELA
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References
- Pizzolla, A; Wing, K; et al. A Glucose-6-Phosphate Isomerase Peptide Induces T and B Cell-Dependent Chronic Arthritis in C57BL/10 Mice Arthritis without Reactive Oxygen Species and Complement. AMERICAN JOURNAL OF PATHOLOGY 183:1144-1155(2013).
- Savchenko, VL; et al. Regulation of NADPH Oxidase Gene Expression with PKA and Cytokine IL-4 in Neurons and Microglia. NEUROTOXICITY RESEARCH 23:201-213(2013).
