NBN
-
Official Full Name
nibrin -
Overview
Nibrin, a ~95 kDa double stranded DNA repair protein,Is mutated in Nijmegen breakage syndrome (NBS). Patients with NBS exhibit chromosomal instability, resulting in hypersensitivity to irradiation and cancer predisposition. Nibrin forms a manganese-sensitive complex with hMre11 and hRAD50 that has single strand DNA endonuclease and exonuclease activities and is likely to be important for DNA excision, repair, and stability. This nibrin/Mre11/RAD50 complex is inhibited by BRCA1. The ATM (ataxia telangiectasia mutated) kinase has been shown to phosphorylate nibrin in an S-phase checkpoint pathway. Nibrin levels are elevated in testis tissue, suggesting a possible role in meiotic recombination. Nibrin may also be involved in telomere length maintenance. -
Synonyms
NBN;nibrin;NBS, NBS1, Nijmegen breakage syndrome 1 (nibrin);AT V1;AT V2;ATV;cell cycle regulatory protein p95;Nijmegen breakage syndrome 1 (nibrin);p95 protein of the MRE11/RAD50 complex;NBS;P95;NBS1;AT-V1;AT-V2;FLJ10155;MGC87362
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Chicken
- E. coli
- Mammalian Cell
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
Involved Pathway
NBN involved in several pathways and played different roles in them. We selected most pathways NBN participated on our site, such as Homologous recombination, which may be useful for your reference. Also, other proteins which involved in the same pathway with NBN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Homologous recombination | SYCP3,RAD51B,RAD51L1,MRE11A,RPA4,POLD4,SSBP1,XRCC3,RAD51C,RAD52 |
Protein Function
NBN has several biochemical functions, for example, contributes_to ATP-dependent DNA helicase activity,contributes_to damaged DNA binding,protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NBN itself. We selected most functions NBN had, and list some proteins which have the same functions with NBN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | ZEB1,PRKDC,SIRT1,HES3,EPAS1,JUND,SOX8,PPP1R13L,DDIT3,GATA4 |
| contributes_to ATP-dependent DNA helicase activity | MRE11A,MCM6,MCM4,RAD50,MCM7 |
| contributes_to damaged DNA binding | DDB1,CUL4B,DDB2 |
| protein binding | ID4,KIRREL2,CDC42EP5,RSPO1,TRIP12,TNFRSF1A,HK2,VAMP2,BLK,IL2RB |
| protein N-terminus binding | STX5A,NTSR1,RELA,NCOR2,PARP1,ACOX1,DAXX,ARF6,TAF11,PEX14 |
Interacting Protein
NBN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NBN here. Most of them are supplied by our site. Hope this information will be useful for your research of NBN.
MDC1
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