NAGLU
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Official Full Name
N-acetylglucosaminidase, alpha -
Overview
This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate. [provided by RefSeq, Jul 2008] -
Synonyms
NAGLU;N-acetylglucosaminidase, alpha;NAG;MPS3B;UFHSD;MPS-IIIB;alpha-N-acetylglucosaminidase;N-acetyl-alpha-glucosaminidase
Recombinant Proteins
- Human
- Mouse
- Rat
- CHO
- Wheat Germ
- E.coli
- His
- Non
- His&T7
- His&GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NAGLU-1901H | Recombinant Human NAGLU, His-tagged | CHO | Human | His | 1-743 a.a. | |
| NAGLU-27921TH | Recombinant Human NAGLU | Wheat Germ | Human | Non | 99 amino acids |
|
| NAGLU-7905H | Recombinant Human NAGLU protein, His & T7-tagged | E.coli | Human | His&T7 | Val485~Trp743 |
|
| Naglu-7906M | Recombinant Mouse Naglu protein, His & GST-tagged | E.coli | Mouse | His&GST | Arg429~Lys710 |
|
| Naglu-7907R | Recombinant Rat Naglu protein, His & GST-tagged | E.coli | Rat | His&GST | Asn449~Asn709 |
|
| NAGLU-3217M | Recombinant Mouse NAGLU protein, His-tagged | E.coli | Mouse | His | Arg429~Lys710 |
|
| NAGLU-4658H | Recombinant Human NAGLU Protein (Val485-Trp743), N-His tagged | E.coli | Human | His | Val485-Trp743 |
|
| NAGLU-705H | Recombinant Human NAGLU protein, His-tagged | E.coli | Human | His | 394-743 aa |
|
Involved Pathway
NAGLU involved in several pathways and played different roles in them. We selected most pathways NAGLU participated on our site, such as Glycosaminoglycan degradation,Metabolic pathways,Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with NAGLU were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | MAN2B1,ATP6V0C,ATP6V0CB,CTSK,HEXB,CTSJ,PSAPL1,CTSSB.2,ATP6V0A2B,CD164 |
| Glycosaminoglycan degradation | HGSNAT,GNSB,HPSE,SPAM1,IDUA,HEXB,HYAL2,ARSB,GNSA,HYAL4 |
| Metabolic pathways | MTMR7B,ATP6V0B,MAT2B,PLA2G12B,EXT2,ADPGK,PYCR1B,PGM3,PDXK,NDUFA1 |
Protein Function
NAGLU has several biochemical functions, for example, alpha-N-acetylglucosaminidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NAGLU itself. We selected most functions NAGLU had, and list some proteins which have the same functions with NAGLU. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
NAGLU has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NAGLU here. Most of them are supplied by our site. Hope this information will be useful for your research of NAGLU.
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Resources
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References
- Murrey, DA; Naughton, BJ; et al. Feasibility and Safety of Systemic rAAV9-hNAGLU Delivery for Treating Mucopolysaccharidosis IIIB: Toxicology, Biodistribution, and Immunological Assessments in Primates. HUMAN GENE THERAPY CLINICAL DEVELOPMENT 25:72-84(2014).
- Winder-Rhodes, SE; Garcia-Reitbock, P; et al. Genetic and pathological links between Parkinson's disease and the lysosomal disorder Sanfilippo syndrome. MOVEMENT DISORDERS 27:312-315(2012).
