NAGK
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Official Full Name
N-acetylglucosamine kinase -
Overview
N-acetylglucosamine kinase (NAGK; EC 2.7.1.59) converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. NAGK belongs to the group of N-acetylhexosamine kinases and is a prominent salvage enzyme of amino sugar metabolism in mammals. -
Synonyms
NAGK;N-acetylglucosamine kinase;N-acetyl-D-glucosamine kinase;EC 2.7.1.59;GlcNAc kinase;GNK;HSA242910;N acetylglucosamine kinase
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- T7
- His
- Non
- Myc&DDK
- His&Fc&Avi
- His&SUMO
Involved Pathway
NAGK involved in several pathways and played different roles in them. We selected most pathways NAGK participated on our site, such as Amino sugar and nucleotide sugar metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NAGK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | CKMT1A,GALCA,ALDH3A1,NDUFAB1A,ACAT1,ST6GALNAC5,TKTL1,ADKB,PI4K2B,ST3GAL2 |
| Amino sugar and nucleotide sugar metabolism | GPIA,GPR19,GNPDA1,GMPPAB,GKUP,HK1,NANSA,CYB5RL,CMAS,GFPT2 |
Protein Function
NAGK has several biochemical functions, for example, ATP binding,N-acetylglucosamine kinase activity,N-acylmannosamine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NAGK itself. We selected most functions NAGK had, and list some proteins which have the same functions with NAGK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PPP1CA,MAP4K1,NIM1K,DDX43,PSMC3,RAD51C,KIFC1,ATP6V1AA,UBE2KB,GSK3A |
| protein binding | ATP2B1,CRY1A,FBXO46,NLK,POGK,HDAC7A,PLGRKT,CXCR5,CCDC25,PNKD |
| N-acylmannosamine kinase activity | GNE |
Interacting Protein
NAGK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NAGK here. Most of them are supplied by our site. Hope this information will be useful for your research of NAGK.
b2r7w0_human;SDCBP;CDKN2C;MEOX1;REL;TCF12
Resources
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References
- Miura, Y; Sakurai, Y; et al. O-GlcNAc modification affects the ATM-mediated DNA damage response. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1820:1678-1685(2012).
- Geng, F; Zhu, WJ; et al. Multiple post-translational modifications regulate E-cadherin transport during apoptosis. JOURNAL OF CELL SCIENCE 125:2615-2625(2012).
