MTA1
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Official Full Name
metastasis associated 1 -
Overview
MTA1 (metastasis associated gene 1) was identified in a differential screening of a cDNA library of metastatic and nonmetastatic adenocarcinoma cell lines (1), and was subsequently found to be an integral member of the nucleosome remodeling and deacetylat -
Synonyms
MTA1;metastasis associated 1;metastasis-associated protein MTA1;metastasis associated gene 1 protein
Recombinant Proteins
- Chicken
- Human
- Mouse
- Rat
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- GST
- DDK
- Myc
- Non
- Flag
- Avi
- Fc
Involved Pathway
MTA1 involved in several pathways and played different roles in them. We selected most pathways MTA1 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin organization | ARID5B,ZZZ3,PHF2,SUZ12,SMARCA2,SMARCD3,ELP4,JADE1,SMYD2,SMARCD1 |
| RNA Polymerase I Transcription Initiation | MBD3B,GATAD2B,UBTF,CHD4A,MBD3,RRN3,GATAD2A,MTA3,CHD4,MTA2 |
| RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription | TFB2M,SNAPC5,GATAD2A,MTA3,POLRMT,GATAD2AB,GATAD2B,RRN3,GTF3AA,NFIC |
| Chromatin modifying enzymes | KDM5BB,COPRS,ATXN7,PRMT7,PHF21A,SUZ12,SMARCD3,PADI4,RUVBL2,TADA2A |
| RNA Polymerase I Transcription | PTRF,MTA2,GATAD2AB,GATAD2B,CHD4A,CBX3A,EFCAB11,CD3EAP,GATAD2A,TAF1B |
| RNA Polymerase I Promoter Clearance | MTA2,MBD3B,MBD3,CHD4A,EFCAB11,MTA3,CD3EAP,TAF1B,GATAD2AB,RRN3 |
| HDACs deacetylate histones | MBD3A,PHF21A,MBD3B,KDM1A,SAP30,MBD3,MTA3,GATAD2AB,HMG20B,SUDS3 |
| Gene Expression | ZNF643,ZFP28,ZNF253,POU2F1B,ZNF426,ARHGEF38,ZNF19,BAZ2A,MED16,ZNF45 |
Protein Function
MTA1 has several biochemical functions, for example, RNA polymerase II repressing transcription factor binding,chromatin binding,core promoter binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTA1 itself. We selected most functions MTA1 had, and list some proteins which have the same functions with MTA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | MKL1,MEOX2,TEAD1,FOXO1A,NR2F2,PAX7,ZNF227,TEAD3,LCOR,ZNF792 |
| core promoter sequence-specific DNA binding | NR1D1,SIRT1,SOHLH2,SOX4,C1orf51,SOX1,NFYA,TRP53,PDX1,CHD2 |
| enzyme binding | DAXX,PLCE1,SIRT3,RCOR3,RYR2,MST1R,IL6R,UGT1A6,HSPA1A,CBX3 |
| transcription coactivator activity | MAML2,SCAND1,CBFB,SMARCD1,BCL10,WNT3A,MED17,ASXL1,SP4,E4F1 |
| chromatin binding | TBL1Y,PBRM1L,SFPQ,TADA2B,BRD3,PHF13,PRDM13,AAAS,PHF8,HOXD10 |
| protein binding | TSSK1,KLB,STOX1,CCPG1,SARM1,EPS8L1,MAVS,DEFA6,C7orf42,POR |
| core promoter binding | REST,CCAR1,CALCOCO1,CRY1,NPAS2,E2F7,HDAC1,RB1,SFPI1,EZH2 |
| RNA polymerase II repressing transcription factor binding | MIXL1,MKKS,TBX5A,BBS2,CHD4,STAT3,HDAC1,GATA6,GTF2A2,HDAC2 |
| zinc ion binding | TRIM72,SH3RF1,ADAM7,RNF175,ADAM33,TRIM32,TRIM59,GALT,ZDHHC24,MME |
Interacting Protein
MTA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MTA1.
HDAC1;HDAC2;ESR1;MAGEA11;KRTAP10-8;RBBP4
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References
- Soler, DM; Ghosh, A; et al. A single element in the 3 ' UTR of the apical sodium-dependent bile acid transporter controls both stabilization and destabilization of mRNA. BIOCHEMICAL JOURNAL 462:547-553(2014).
- Park, JO; Jung, CK; et al. Relationships between metastasis-associated protein (MTA) 1 and lymphatic metastasis in tonsil cancer. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY 268:1329-1334(2011).
