MAP3K9
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Official Full Name
mitogen-activated protein kinase kinase kinase 9 -
Overview
Mixed-lineage kinases (MLKs) belong to the mitogen activated kinase kinase kinase (MAPKKK) family of dual-specificity protein kinases. While not particularly well conserved at the sequence level, MLK1, 2 and 3 share a conserved domain structure consisting -
Synonyms
MAP3K9;mitogen-activated protein kinase kinase kinase 9;MLK1;MEKK9;PRKE1;mixed lineage kinase 1 (tyr and ser/thr specificity)
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MAP3K9-3052H | Recombinant Human MAP3K9 protein, His-tagged | E.coli | Human | His | 575-821 aa | |
| MAP3K9-1040H | Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 9, GST-Tagged | Sf9 Cells | Human | GST | 1-433 a.a. |
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| MAP3K9-1262H | Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 9, GST-tagged | Insect Cells | Human | GST | 1-500 a.a. |
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| MAP3K9-9519M | Recombinant Mouse MAP3K9 Protein | Mammalian Cells | Mouse | His |
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| MAP3K9-5336M | Recombinant Mouse MAP3K9 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| MAP3K9-5336M-B | Recombinant Mouse MAP3K9 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
MAP3K9 involved in several pathways and played different roles in them. We selected most pathways MAP3K9 participated on our site, such as Insulin Signaling,p38 MAPK Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| p38 MAPK signaling pathway | MAP3K10,GADD45G |
| Insulin Signaling | EHD1,GRB10,MAP4K1,MAP4K5,SNAP25A,GSK3AB,REG1A,KIF5B,MAPK6,ARHGAP33 |
Protein Function
MAP3K9 has several biochemical functions, for example, ATP binding,JUN kinase kinase kinase activity,MAP kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K9 itself. We selected most functions MAP3K9 had, and list some proteins which have the same functions with MAP3K9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| JUN kinase kinase kinase activity | MAP3K11,MAP3K1,ALPK2,MAP3K10 |
| ATP binding | KDR,RARS,CMPK1,CAMK2B1,BMPR1A,MARS2,NLRP2,EIF4A3,SPEG,UBE2IA |
| protein homodimerization activity | PRDM6,ENPP1,ODZ4,KCNE2,ACTN3,RNF40,CTBP2A,ATP2A1,BCL2A1,GLIPR2 |
| protein tyrosine kinase activity | FGFR3,EK1,SRC,EPHA4B,IGF1R,RET,DYRK1A,MAP2K6,ZAP70,ERBB3A |
| protein serine/threonine kinase activity | BSK146,NUAK2,SIK3,MAST2,WNK2,PAK4,RPS6KAL,NEK10,WNK1,ERN2 |
| protein binding | PTRF,S1PR2,NDUFS3,DSN1,PYGM,HIST1H2AH,CAMK2A,SUDS3,MXD3,MMP20 |
| MAP kinase kinase activity | MAPK14,MAP3K14,MAP2K3,MAP2K2B,MAP2K2A,PAK3,MAPKAPK5,SBK3,MAPK10,LRRK2 |
Interacting Protein
MAP3K9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K9 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K9.
HSP90AB1;abl-tide
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References
- Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).
- Jeon, JH; Kim, YH; et al. Bacillus anthracis genomic DNA enhances lethal toxin-induced cytotoxicity through TNF-alpha production. BMC MICROBIOLOGY 14:-(2014).
