Lhcgr
-
Official Full Name
luteinizing hormone/choriogonadotropin receptor -
Overview
This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. -
Synonyms
LHCGR;luteinizing hormone/choriogonadotropin receptor;HHG, hypergonadotropic hypogonadism;lutropin-choriogonadotropic hormone receptor;LCGR;LGR2;LHR;ULG5;hypergonadotropic hypogonadism;lutropin/choriogonadotropin receptor;HHG;LHRHR;LSH-R;LH/CGR;LH/CG-R;FLJ41504;LH/Hcg Receptor, Extracellular Domain
Recombinant Proteins
- Zebrafish
- Rat
- Chicken
- Mouse
- Human
- Mus musculus
- Sheep
- Callithrix jacchus (White-tufted-ear marmoset)
- Bovine
- Sus scrofa (Pig)
- Mammalian Cell
- E.coli
- HEK293
- Yeast
- E.coli expression system
- His
- His&Flag
- His&Fc&Avi
- Flag
- His&SUMO
- Non
Involved Pathway
Lhcgr involved in several pathways and played different roles in them. We selected most pathways Lhcgr participated on our site, such as Calcium signaling pathway,Neuroactive ligand-receptor interaction,Ovarian steroidogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Lhcgr were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | TACR3L,ITPR3,P2RX3,TBXA2R,CACNA1SA,CHRM1,CACNA1DA,ADRA1BB,SPHK2,RYR2 |
| Neuroactive ligand-receptor interaction | GABRA3,TAAR1B,APLNRB,ADRB3B,CGNRH-R,F2RL1.1,APLNRA,TAAR7F,CHRNA2,GABRB1 |
| Prolactin signaling pathway | MAPK10,TNFRSF11A,INS2,SOCS7,STAT5B,FOS,SHC2,KRAS,SOCS2,MAPK13 |
| Ovarian steroidogenesis | PLA2G4F,SCARB1,GDF9,INS1,INSR,GNAS,PRKACG,HSD3B2,HSD17B7,LHB |
Protein Function
Lhcgr has several biochemical functions, for example, G-protein coupled peptide receptor activity,choriogonadotropin hormone binding,choriogonadotropin hormone receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Lhcgr itself. We selected most functions Lhcgr had, and list some proteins which have the same functions with Lhcgr. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled peptide receptor activity | NPR3,GPR84,LTB4R2,RXFP4,RXFP3.2B,TSHR,GPR37,LTB4R,NPR1,GPR37L1 |
Interacting Protein
Lhcgr has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Lhcgr here. Most of them are supplied by our site. Hope this information will be useful for your research of Lhcgr.
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References
- Liaqat, I; Jahan, N; et al. Genetic Polymorphisms in Pakistani Women With Polycystic Ovary Syndrome. REPRODUCTIVE SCIENCES 22:347-357(2015).
- McAllister, JM; Legro, RS; et al. Functional genomics of PCOS: from GWAS to molecular mechanisms. TRENDS IN ENDOCRINOLOGY AND METABOLISM 26:118-124(2015).
