Lama3
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Official Full Name
laminin, alpha 3 -
Overview
Laminins are basement membrane components thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. The protein encoded by this gene is the alpha-3 subunit of laminin 5, which is a complex glycoprotein composed of three subunits (alpha, beta, and gamma). Laminin 5 is thought to be involved in cell adhesion, signal transduction and differentiation of keratinocytes. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. -
Synonyms
LAMA3;laminin, alpha 3;BM600, E170, LAMNA, LOCS, lama3a;BM600 150kD subunit;epiligrin 170 kda subunit;epiligrin alpha 3 subunit;epiligrin subunit alpha;kalinin 165kD subunit;kalinin subunit alpha;laminin subunit alpha-3;laminin, alpha 3 (nicein (150kD), kalinin (165kD), BM600 (150kD), epilegrin);laminin-5 alpha 3 chain;laminin-5 subunit alpha;laminin-6 subunit alpha;laminin-7 subunit alpha;nicein 150kD subunit;nicein subunit alpha
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LAMA3-2946H | Recombinant Human LAMA3 protein, His-tagged | E.coli | Human | His | 1972-2110 aa | |
| LAMA3/LAMB3/LAMC2-512H |
Active Recombinant Human LAMA3 & LAMB3 & LAMC2 protein
|
Human | Non |
|
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| LAMA3-4828HCL | Recombinant Human LAMA3 293 Cell Lysate | HEK293 | Human | Non |
|
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| LAMA3-212H | Recombinant Human LAMA3 Protein, His-tagged | E.coli | Human | His | Gln47~Leu296 |
|
| LAMA3-301437H | Recombinant Human LAMA3 protein, GST-tagged | E.coli | Human | GST | Glu1972-Lys2110 |
|
Involved Pathway
Lama3 involved in several pathways and played different roles in them. We selected most pathways Lama3 participated on our site, such as PIK-Akt signaling pathway,Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with Lama3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathways in cancer | LAMA4,XIAP,VEGFB,TCEB2,PPARG,HDAC2,PRKACB,FOXO1,TRAF4,RASGRP3 |
| Focal adhesion | MYL9B,LAMB1,RAC1B,FLNA,SHC2,MYL12.2,PDGFRA,PAK4,DOCK1,CAPN2B |
| PIK-Akt signaling pathway | FGF13,EIF4E1B,GH2,ITGA10,RELA,IRS1,ITGB6,FGF11,FGF22,PPP2R5C |
| ECM-receptor interaction | COL24A1,ITGA2B,COL4A6,CHAD,COL27A1B,LAMB2,COL3A1,LAMA2,COL4A4,COMP |
| Toxoplasmosis | HLA-DRB5,IFNG,BIRC2,TNFRSF1A,PIK3R1,PPIF,IL10RA,MAP3K7,HLA-DRB4,IL10RB |
| Amoebiasis | PIK3CA,LAMC2,COL5A1,PRKCB,SERPINB3C,SERPINB13,LAMC3,COL4A1,CSF2,GNA11 |
| Small cell lung cancer | LAMB3,ITGA2,CYCS,CCND1,LAMC1,RELA,ITGA6,PIK3R1,NFKBIA,IKBKB |
Protein Function
Lama3 has several biochemical functions, for example, receptor binding,structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Lama3 itself. We selected most functions Lama3 had, and list some proteins which have the same functions with Lama3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | GNPAT,PVRL4,HTT,APOL2,NPPC,KNG1,TIGIT,NCK1,TYROBP,NRG2A |
| structural molecule activity | CLDN18,TUBG2,SYNC,NEFMA,RLN3B,CLDNE,KRT25,TUBA1B,LAD1,BVES |
Interacting Protein
Lama3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Lama3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Lama3.
SIRT1;APC;SLC35E1
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References
- Ullah, M; Sittinger, M; et al. Extracellular matrix of adipogenically differentiated mesenchymal stem cells reveals a network of collagen filaments, mostly interwoven by hexagonal structural units. MATRIX BIOLOGY 32:452-465(2013).
- Yuen, WY; Lemmink, HH; et al. Herlitz junctional epidermolysis bullosa: diagnostic features, mutational profile, incidence and population carrier frequency in the Netherlands. BRITISH JOURNAL OF DERMATOLOGY 165:1314-1322(2011).
