LYVE1
-
Official Full Name
lymphatic vessel endothelial hyaluronan receptor 1 -
Overview
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. -
Synonyms
LYVE1;lymphatic vessel endothelial hyaluronan receptor 1;Xlkd1;Lyve-1;Crsbp-1;1200012G08Rik;lymphatic vessel endothelial hyaluronic acid receptor 1;extra cellular link domain-containing 1;lymphatic vessel endothelial HA recptor-1;lymphatic vessel endothelial HA receptor-1;extracellular link domain-containing protein 1;cell surface retention sequence binding protein-1;cell surface retention sequence-binding protein 1;HAR
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Insect Cell
- Human
- Mouse
- HEK293
- Human Cell
- NS0
- Mammalian cells
- Non
- Fc
- His
- GST
- C-His&Flag
Involved Pathway
LYVE1 involved in several pathways and played different roles in them. We selected most pathways LYVE1 participated on our site, such as Glycosaminoglycan metabolism,Hyaluronan metabolism,Hyaluronan uptake and degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with LYVE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | MED29,ACOT11B,SULT2ST1,ADA,APOA4B.1,ACMSD,B3GNT3,HAS3,MAPK1IP1L,DGAT1B |
| Metabolism of carbohydrates | CHP,UST,HAS3,SLC25A10,HPSE,TREH,B3GNT1,SLC26A1,SLC35B3,AGL |
| Glycosaminoglycan metabolism | FMODA,GPC1B,DSEL,HS3ST4,B3GAT2,BGNA,GPC5A,B4GALT7,B3GNT2,KIAA1199 |
| Hyaluronan metabolism | HAS1,HAS3,CHP,STAB2,KIAA1199 |
| Hyaluronan uptake and degradation | STAB2,CHP |
Protein Function
LYVE1 has several biochemical functions, for example, hyaluronic acid binding,protein binding,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LYVE1 itself. We selected most functions LYVE1 had, and list some proteins which have the same functions with LYVE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | VPS29,XK,STAMBP,AGO2,ZFYVE16,PPM1B,ACSF2,MED24,TRPC3,SPHK2 |
| hyaluronic acid binding | STAB2,VCANB,HYAL2,HAPLN4,HAPLN3,CD44,C1QBP,LAYN,HAPLN2,ACAN |
| receptor activity | ANPEP,NLGN4B,ADIPOR1B,NRXN1,ABP1,CMKLR1,CADM1B,CALCR,NLGN3,GUCY1B3 |
| transmembrane signaling receptor activity | TLR9,MARCO,GP6,TLR18,GPR126,GHRHRA,CD4,LGR6,CD3E,CELSR1 |
Interacting Protein
LYVE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LYVE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LYVE1.
KRTAP10-8
Resources
Research Area
Endothelial Cell Development MoleculesEndothelial Cell Markers
Hyaluronan (HA) binding Proteins
Related Services
Related Products
References
- Park, SM; Angel, CE; et al. Mapping the Distinctive Populations of Lymphatic Endothelial Cells in Different Zones of Human Lymph Nodes. PLOS ONE 9:-(2014).
- Davis, JM; Hyjek, E; et al. Lymphatic Endothelial Differentiation in Pulmonary Lymphangioleiomyomatosis Cells. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 61:580-590(2013).
