LRRK2
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Official Full Name
leucine-rich repeat kinase 2 -
Overview
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a;leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain,;and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer;membrane. Mutations in this gene have been associated with Parkinson disease-8. -
Synonyms
LRRK2;leucine-rich repeat kinase 2;PARK8, Parkinson disease (autosomal dominant) 8;leucine-rich repeat serine/threonine-protein kinase 2;DKFZp434H2111;FLJ45829;RIPK7;ROCO2;augmented in rheumatoid arthritis 17;PARK8;AURA17;DARDARIN
Recombinant Proteins
- Human
- Mouse
- Sf9 Cells
- Insect Cells
- Mammalian Cells
- HEK293
- E.coli
- Wheat Germ
- GST
- Flag
- DDK&Myc
- Avi&Fc&His
- His
- GST&His
Involved Pathway
LRRK2 involved in several pathways and played different roles in them. We selected most pathways LRRK2 participated on our site, such as MAPK signaling pathway,Parkinsons disease,Parkinsons Disease Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRRK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | MAPK14B,FGF9,CASP3B,FGFR4,PAK2,RRAS2,EGFRA,NTF4,RASGRP3,FGF17 |
| Parkinsons Disease Pathway | UBE2J2,ATXN2,PARK7,SYT11 |
| Wnt Signaling Pathway and Pluripotency | FBXW2,ZBTB33,PPM1J,FOXD3 |
| Parkinsons disease | DRD1A,ATP5G3,PARK7,NDUFB2,SLC25A6,MT-ND1,NDUFC2,PINK1,COX8C,mt-Atp8 |
Protein Function
LRRK2 has several biochemical functions, for example, ATP binding,GTP binding,GTP-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LRRK2 itself. We selected most functions LRRK2 had, and list some proteins which have the same functions with LRRK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | ARHGAP4,ADAP1,RGS5,DLC1,GRTP1A,RGS7,ARHGAP9,ARFGAP2,ANKRD27,TSC2 |
| ATP binding | DYRK1AA,MYH7B,SIK2,CDKL2,GTF2F2B,ACVR1,SNRNP200,EIF2AK2,PRKAG2,EPHA4B |
| tubulin binding | KIF14,TPPP3,PRNP,ATF5,STMN1B,STMN1A,AGBL4,TBCA,TPR,BRCA1 |
| identical protein binding | APOH,C1QL2,CST3,PYCARD,G6PD,TRIM5,PUF60,WRNIP1,LZTFL1,ASMT |
| receptor signaling complex scaffold activity | ROPN1B,MAPK8IP3,RGS14,CD3E,GRIP1,DEDD2,MMS19,G3BP2,NCK1,AXIN1 |
| protein kinase activity | STK38A,DAPK2A,MKNK2A,EPHB3A,CDK5,TSSK5,TBRG4,SGK2B,EK1,MAP3K10 |
| protein serine/threonine kinase activity | BUB1B,TGFBR1,PHKG1A,STK11,SNRKA,CSNK1D,MARK4,MAP2K2A,LATS2,TSSK1 |
| SNARE binding | MYO5A,STX2A,STX1B,YKT6,UVRAG,STX4A,TNFAIP2,GABARAPL2,SNAPIN,STX7 |
| syntaxin-1 binding | RNF40,DAPK1,GOLSYN,UNC13A,SLC6A4,SNPH,STXBP3A,SNAP25A,SYT1,STXBP2 |
Interacting Protein
LRRK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRRK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LRRK2.
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References
- West, AB; Cowell, RM; et al. Differential LRRK2 Expression in the Cortex, Striatum, and Substantia Nigra in Transgenic and Nontransgenic Rodents. JOURNAL OF COMPARATIVE NEUROLOGY 522:2465-2480(2014).
- Alvarez-Castelao, B; Gorostidi, A; et al. Epitope mapping of antibodies to alpha-synuclein in LRRK2 mutation carriers, idiopathic Parkinson disease patients, and healthy controls. FRONTIERS IN AGING NEUROSCIENCE 6:-(2014).
