LPL
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Official Full Name
Lipoprotein Lipase -
Overview
LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. -
Synonyms
LIPD;HDLCQ11;EC 3.1.1.34;LPL;lipoprotein lipase;MGC137861;OTTHUMP00000034806
Recombinant Proteins
- Human
- Rat
- Cynomolgus
- Chicken
- Zebrafish
- Mouse
- Chinese hamster
- E.coli
- HEK293
- Mammalian Cell
- Mammalian cells
- HEK293T
- Insect Cell
- Wheat Germ
- In Vitro Cell Free System
- his
- Flag
- His
- Non
- His&Myc
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
LPL involved in several pathways and played different roles in them. We selected most pathways LPL participated on our site, such as Glycerolipid metabolism,PPAR signaling pathway,Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alzheimers disease | GRIN1,COX6B2,PLCB3,NOS1,FADD,MAPT,COX6A1,NDUFS1,GRIN2C,CASP7 |
| PPAR signaling pathway | FABP7B,ACSL1,CYP7A1A,RXRG,APOA1,ACOX3,FADS2,ACSBG2,ACSBG1,RXRA |
| Glycerolipid metabolism | DGKAA,LIPCA,LCLAT1,DGAT2,DGAT1,AGK,DGKZ,AGPAT3,ALDH1B1,MOGAT3A |
Protein Function
LPL has several biochemical functions, for example, apolipoprotein binding,heparin binding,lipoprotein lipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LPL itself. We selected most functions LPL had, and list some proteins which have the same functions with LPL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lipoprotein lipase activity | AOAH,LIPG |
| protein binding | THBS4,C5orf13,GRIN1,RIN1,SUV420H2,LMO1,PAX3,CCPG1,BNIPL,RSPH1 |
| triglyceride lipase activity | Cel,CEL.1,CES5A,PNLIPRP1,CES1D,LIPF,AADAC,LIPC,PNLIPRP3,PNPLA2 |
| triglyceride binding | CETP |
| heparin binding | FGFRL1,PDCD5,PTPRF,POSTN,CCL2,SFRP1,PTPRFB,GREM2,CXCL11,APLP2 |
| apolipoprotein binding | LRP4,LPA,LRP6,ABCA1,MAPT,VLDLR,PLG,SCARB1,LIPC,LRP1 |
| receptor binding | SSFA2,ACOT2,WNT2BA,MBL2,CD70,BMP3,NTF3,SERPINE2,TNFSF13,CXCL12 |
| phospholipase activity | NOTUM1A,DAGLB,PNLIPRP2,LIPI,LIPH,PLA2G4AA,CEL.1,ABHD6,LIPG,LIPC |
Interacting Protein
LPL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPL here. Most of them are supplied by our site. Hope this information will be useful for your research of LPL.
APOA5;SORT1;GPIHBP1;CCND1;PTPN4;RPL18A;COPS6;ASCC2;UBE2Z;CEP126;LUC7L2;PLK1
Resources
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References
- Beigneux, AP; Fong, LG; et al. GPIHBP1 Missense Mutations Often Cause Multimerization of GPIHBP1 and Thereby Prevent Lipoprotein Lipase Binding. CIRCULATION RESEARCH 116:624-U152(2015).
- Toth-Liptak, J; Piukovics, K; et al. A Comprehensive Immunophenotypic Marker Analysis of Hairy Cell Leukemia in Paraffin-Embedded Bone Marrow Trephine Biopsies-A Tissue Microarray Study. PATHOLOGY & ONCOLOGY RESEARCH 21:203-211(2015).
