LLGL2
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Official Full Name
lethal giant larvae homolog 2 -
Overview
The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the proteins ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
LLGL2;lethal giant larvae homolog 2 (Drosophila);lethal giant larvae (Drosophila) homolog 2;lethal(2) giant larvae protein homolog 2;HGL;human giant larvae homolog;LGL2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LLGL2-11861Z | Recombinant Zebrafish LLGL2 | Mammalian Cell | Zebrafish | His |
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| LLGL2-29145TH | Recombinant Human LLGL2 | Wheat Germ | Human | Non | 99 amino acids |
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| LLGL2-4720HCL | Recombinant Human LLGL2 293 Cell Lysate | HEK293 | Human | Non |
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| Llgl2-3795M | Recombinant Mouse Llgl2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
LLGL2 involved in several pathways and played different roles in them. We selected most pathways LLGL2 participated on our site, such as Hippo signaling pathway,Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LLGL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hippo signaling pathway | BMP8B,WNT16,TEAD2,RASSF1,YWHAG,WNT9A,ITGB2L,WNT8B,BMPR1B,GSK3B |
| Tight junction | ACTN2,CLDN1,MYL5,ACTB2,PRKCH,EPB41L3B,MPP5,PARD6B,MAGI2,CLDN5 |
Protein Function
LLGL2 has several biochemical functions, for example, GTPase activator activity,PDZ domain binding,Rab GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LLGL2 itself. We selected most functions LLGL2 had, and list some proteins which have the same functions with LLGL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| PDZ domain binding | SLC9A3R2,TGFBR3,ACVR2A,ATP2B1A,DLG1,MAP2K2,FZD1,PTENA,NKD1,DOCK4 |
| protein binding | BCDIN3D,CCDC116,JOSD1,PIP4K2B,MEMO1,GLYCTK,SMAD1,BSG,ZNF180,CBX6 |
| NOT syntaxin binding | C2CD4A,TC2N,C2CD4B,LLGL1 |
| GTPase activator activity | ASAP3,LLGL1,TBC1D16,DLC1,RGS18,RGS5,TIAM2,TSC2,RGS11,ARHGAP40 |
| Rab GTPase binding | RAB11FIP4,RAB11FIP4A,RABGEF1,MYO5B,ULK1,PPIAL4A,GAS8,LLGL1,MICALL1,DENND5A |
Interacting Protein
LLGL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LLGL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LLGL2.
PRKCI;PARD6B;PARD6A;ssrna_uc;ATF2;RBBP6
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References
- Kohn, KW; Zeeberg, BM; et al. Gene Expression Correlations in Human Cancer Cell Lines Define Molecular Interaction Networks for Epithelial Phenotype. PLOS ONE 9:-(2014).
- Linch, M; Sanz-Garcia, M; et al. A Cancer-Associated Mutation in Atypical Protein Kinase C iota Occurs in a Substrate-Specific Recruitment Motif. SCIENCE SIGNALING 6:-(2013).
