LIN28B
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Official Full Name
lin-28 homolog B -
Overview
LIN28A and LIN28B are conserved, developmentally regulated RNA binding proteins that inhibit the processing and maturation of the let-7 family of miRNAs. The let-7 miRNAs have been implicated in repression of oncogenes such as ras, myc, and Hmga2. It has -
Synonyms
LIN28B;lin-28 homolog B (C. elegans);protein lin-28 homolog B;CSDD2;FLJ16517;lin-28B;Lin-28.2
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Mouse
- Mammalian Cell
- E.coli
- HEK293
- His
- Non
- Flag&Avi
- His&Fc&Avi
Involved Pathway
LIN28B involved in several pathways and played different roles in them. We selected most pathways LIN28B participated on our site, such as Cardiac Progenitor Differentiation,Validated targets of C-MYC transcriptional activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIN28B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cardiac Progenitor Differentiation | TBX20,IRX4,NKX2,LIN28A,SOX1,ZFP42,NOG,ROR2,NIPAL1,SIRPA |
| Validated targets of C-MYC transcriptional activation | NDUFAF2,PEG10,PDCD10,HUWE1,SERPINI1,MYCT1,MTDH,MINA,DDX18,IREB2 |
Protein Function
LIN28B has several biochemical functions, for example, DNA binding,RNA binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIN28B itself. We selected most functions LIN28B had, and list some proteins which have the same functions with LIN28B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | EIF4E3,DAZAP1,PCBP4,SF3B3,TUT1,CSTF3,SETD1B,TARDBP,HNRPL,RPL18 |
| protein binding | IL5,C11orf68,LMAN1,HNRNPA1,CD247,SHC1,ATP6V1D,TBPL1,TAPBP,TEAD4 |
| DNA binding | ZNF74,ZNF566,HOXD9A,MCM8,HOXB1B,CDT1,NFE2L1A,KLF3,NKX6.2,OTUD7A |
| zinc ion binding | RNF40,RORCB,ZNF184,KDM5D,RNF138,CA4,MBD1B,MT1A,HRG,ZFP326 |
| poly(A) RNA binding | HIST1H4L,DDX27,NOA1,RPLP0,ERH,HIST1H47,CORO1A,SNRPA1,NHP2,TFB2M |
Interacting Protein
LIN28B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIN28B here. Most of them are supplied by our site. Hope this information will be useful for your research of LIN28B.
pre-let-7a;YBX1;pre-mir-107;ZCCHC11;USP36;ssrna_cg
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References
- Williams, KA; Labidi-Galy, SI; et al. Prognostic significance and predictors of the neutrophil-to-lymphocyte ratio in ovarian cancer. GYNECOLOGIC ONCOLOGY 132:542-550(2014).
- Helland, A; Anglesio, MS; et al. Deregulation of MYCN, LIN28B and LET7 in a Molecular Subtype of Aggressive High-Grade Serous Ovarian Cancers. PLOS ONE 6:-(2011).
- Guo, YQ; Chen, YX; et al. Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma. GENE 384:51-61(2006).
