LIMK2
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Official Full Name
LIM domain kinase 2 -
Overview
LIM kinases (LIMK1 and LIMK2) are serine/threonine kinases that have two zinc finger motifs, known as LIM motifs, in their amino-terminal regulatory domains (1). LIM kinases are involved in actin cytoskeletal regulation downstream of Rho-family GTPases, P -
Synonyms
LIMK2;LIM domain kinase 2
Recombinant Proteins
- Rat
- Human
- Chicken
- Zebrafish
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- Sf21 Cells
- His
- His&GST
- Non
- His&Fc&Avi
- GST
- Myc&DDK
Involved Pathway
LIMK2 involved in several pathways and played different roles in them. We selected most pathways LIMK2 participated on our site, such as Axon guidance,Fc gamma R-mediated phagocytosis,Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIMK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Actin Cytoskeleton | MAPK6,BAIAP2A,ITGA4,MYLK4,Pdgfa&Pdgfb,LIMK1A,ACTN2B,ITGB1A,MYL9A,FGF1 |
| Axon guidance | SEMA4B,KALRNB,SEMA6A,COL4A3,EFNA4,FRS2B,RAC2,NRP1,DUSP7,NRP1A |
| Fc gamma R-mediated phagocytosis | PIK3CG,ASAP1,VAV1,PIP5K1B,WASF2,PRKCB,RAC1,FCGR1,MARCKSL1,WASL |
Protein Function
LIMK2 has several biochemical functions, for example, ATP binding,protein binding,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LIMK2 itself. We selected most functions LIMK2 had, and list some proteins which have the same functions with LIMK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | NR0B1,ASB7,ADAR,WHSC1,CKM,CXCR2,STAT4,LYN,TCAP,CIAPIN1 |
| zinc ion binding | TRAF5,NR1H4,THRA,CRIP2,BMI1,RNF34,ZDHHC15A,ING4,RNF144AB,MNAT1 |
| protein serine/threonine kinase activity | LRRK1,GM711,LMTK3,RPS6KA3B,PRKACAB,EIF2AK4,MOK,RIOK3,TESK1,RAF1B |
| ATP binding | TRPM4,KIF15,DQX1,NADKD1,Acsm2a,RPS6KA4,PGK1,P2RY4,NPR1A,TGFBR1A |
| protein heterodimerization activity | SMC1A,CXCL13,TYR,HIST1H2BK,RALGAPA1,ADRA1B,CEBPE,TAF12,Fzd4,TPD52L1 |
Interacting Protein
LIMK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIMK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LIMK2.
HSP90AB1;CDC37;PARD3;q5ngc7_fratt;HIPK3;linkable pd173955 analogue;bosutinib;crizotinib;CALU;DNAJA2;BAG2;LMNA;HSPB1;ATP1A1;CDK4;EEF2;HSP90B1;DNAJA1;EMD
LIMK2 Related Signal Pathway
Resources
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References
- Acevedo, K; Moussi, N; et al. LIM kinase 2 is widely expressed in all tissues. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 54:487-501(2006).
- Foletta, VC; Moussi, N; et al. LIM kinase 1, a key regulator of actin dynamics, is widely expressed in embryonic and adult tissues. EXPERIMENTAL CELL RESEARCH 294:392-405(2004).
- Toshima, J; Ohashi, K; et al. Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells. JOURNAL OF BIOLOGICAL CHEMISTRY 270:31331-31337(1995).
