LILRA5
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Official Full Name
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 -
Overview
The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. -
Synonyms
LILRA5;leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5;LILRB7;leukocyte immunoglobulin-like receptor subfamily A member 5;CD85;CD85f;ILT11;LIR9;CD85 antigen-like family member F;ILT-11;Immunoglobulin like transcript 11 protein;Immunoglobulin-like transcript 11;Leukocyte Ig like receptor 9;Leukocyte immunoglobulin like receptor subfamily A (with TM domain) member 5;Leukocyte immunoglobulin-like receptor 9;Leukocyte immunoglobulin-like receptor subfamily B (with TM and ITIM domains) member 7;LIR-9;LIRA5_HUMAN;leukocyte Ig-like receptor 9;immunoglobulin-like transcript 11 protein;leukocyte immunoglobulin-like receptor subfamily A member 5 soluble;leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 7
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Mammalian Cells
- Human Cells
- Yeast
- GST
- His&Avi
- His
- Fc
- Non
- His&Fc&Avi
Involved Pathway
LILRA5 involved in several pathways and played different roles in them. We selected most pathways LILRA5 participated on our site, such as Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with LILRA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Osteoclast differentiation | LILRA4,MAP2K7,MAP3K7,PPP3CA,FYN,CYLD,TRAF6,PIK3CA,MAPK3,BTK |
Protein Function
LILRA5 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by LILRA5 itself. We selected most functions LILRA5 had, and list some proteins which have the same functions with LILRA5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
LILRA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LILRA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of LILRA5.
Resources
Research Area
ITIM/ITAM Immunoreceptors and Related MoleculesNeutrophils
Macrophage Markers
Monocyte Markers
Related Services
Related Products
References
- Mitchell, A; Rentero, C; et al. LILRA5 is expressed by synovial tissue macrophages in rheumatoid arthritis, selectively induces pro-inflammatory cytokines and IL-10 and is regulated by TNF-alpha, IL-10 and IFN-gamma. EUROPEAN JOURNAL OF IMMUNOLOGY 38:3459-3473(2008).
- Shiroishi, M; Kajikawa, M; et al. Crystal structure of the human monocyte-activating receptor, "Group 2" leukocyte Ig-like receptor A5 (LILRA5/LIR9/ILT11). JOURNAL OF BIOLOGICAL CHEMISTRY 281:19536-19544(2006).
