LIG3
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Official Full Name
ligase III, DNA, ATP-dependent -
Overview
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. -
Synonyms
LIG3;ligase III, DNA, ATP-dependent;LIG2, ligase II, DNA, ATP dependent;DNA ligase 3;ligase II, DNA, ATP-dependent;polydeoxyribonucleotide synthase [ATP] 3;LIG2
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- GST
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
LIG3 involved in several pathways and played different roles in them. We selected most pathways LIG3 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Base excision repair | SMUG1,xthA,FEN1,POLE2,APEX2,POLE,UNGA,POLE4,PNKP,HMGB1A |
Protein Function
LIG3 has several biochemical functions, for example, ATP binding,DNA binding,DNA ligase (ATP) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LIG3 itself. We selected most functions LIG3 had, and list some proteins which have the same functions with LIG3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | DDX50,STK24A,MOK,ATP2B2,ATP1A1B,CAMK4,ETNK2,INSRB,STK39,ATP2B4 |
| zinc ion binding | RC3H1,CPA6,BAZ2B,TRIM62,KDM7AB,MMP19,ZFP326,DMD,RABGGTB,RNPEPL1 |
| DNA ligase (ATP) activity | LIG4,LIG1 |
| DNA binding | NKX2.1,ALX3,HOXD13A,TAF1L,TNP2,ZNF501,ZBTB7A,ZEB2,THAP5,SCRT2 |
| protein binding | FOXO3B,TMEM31,DNAL4,HSPB8,BAG5,ENC1,DGKZ,CRHR2,PRSS21,PNMA1 |
| DNA ligase activity | LIG4,LIG1 |
Interacting Protein
LIG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of LIG3.
XRCC1;ABL1;SRC;PLCG1;PIK3R1;CRK;PNKP;ssdna_dtdg
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