LIAS
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Official Full Name
lipoic acid synthetase -
Overview
The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. It localizes in mitochondrion and plays an important role in alpha-(+)-lipoic acid synthesis. It may also function in the sulfur insertion chemistry in lipoate biosynthesis. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. -
Synonyms
LIAS;lipoic acid synthetase;lipoyl synthase, mitochondrial;LAS;lip-syn;lipoate synthase;LS;LIP1;PDHLD;HUSSY-01;MGC23245
Recombinant Proteins
- Bacillus subtilis
- Rhesus macaque
- Human
- Rat
- Zebrafish
- Mouse
- E. coli or Yeast
- Mammalian Cell
- E.coli
- E. coli
- HEK293
- His
- N-Twin strep and C-His&Flag
- His&Fc&Avi
- GST
Involved Pathway
LIAS involved in several pathways and played different roles in them. We selected most pathways LIAS participated on our site, such as Lipoic acid metabolism,Metabolic pathways,lipoate biosynthesis and incorporation, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIAS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | PTDSS1A,NDUFS8A,GOT2B,GALNT9,glpK,ADH1C,ALG10B,UGT1A9,POLR2L,COX7C |
| Lipoic acid metabolism | LIPT1,LIPT2 |
Protein Function
LIAS has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding,lipoate synthase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIAS itself. We selected most functions LIAS had, and list some proteins which have the same functions with LIAS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | NR5A1A,FGD4,NAIP7,PLEKHM1P,AMPD3,Car8,ZNF350,MAP2K5,CARS,GM757 |
| 4 iron, 4 sulfur cluster binding | RTEL1,CDKAL1,NDUFS8B,MOCS1,TYW1B,POLD1,ETFDH,ISCA1,ACO1,ACO2 |
Interacting Protein
LIAS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIAS here. Most of them are supplied by our site. Hope this information will be useful for your research of LIAS.
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References
- Roggenbuck, D; Somma, V; et al. Autoantibody profiling in APS. LUPUS 23:1262-1264(2014).
- Roggenbuck, D; Egerer, K; et al. New Approach in the Diagnostics of Antiphospholipid Syndrome. AKTUELLE RHEUMATOLOGIE 39:58-63(2014).
