LGR6

  • Official Full Name

    leucine-rich repeat containing G protein-coupled receptor 6

  • Overview

    This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants.

  • Synonyms

    LGR6;leucine-rich repeat containing G protein-coupled receptor 6;leucine rich repeat containing G protein coupled receptor 6;leucine-rich repeat-containing G-protein coupled receptor 6;FLJ14471;gonadotropin receptor;leucine-rich repeat-containing G

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • CHO
  • Yeast
  • His
  • GST
  • Flag
  • mFc
  • Fc
  • Non
  • His&Fc&Avi

    Involved Pathway

    LGR6 involved in several pathways and played different roles in them. We selected most pathways LGR6 participated on our site, such as GPCRs, Other,Regulation of FZD by ubiquitination,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LGR6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TCF dependent signaling in response to WNT SOX32,PYGO2,RSPO4,LEO1,SRY,DACT1,SOX9A,KREMEN1,ASH2L,LGR5
    GPCRs, Other CELSR2,VMN1R41,ADORA3,EMR2,GPR55,V1RA8,VMN1R148,GPR183,VMN1R44,S1PR1
    Signal Transduction GAL,PYYA,ASH2L,APOA4A,PRDM4,ARHGAP8,OR52J3,RHOF,CGNB,S1PR5B
    Signaling by Wnt ASH2L,WIF1,AES,CBY1,PYGO1,LGR4,SOX9A,SOX6,RNF146,HECW1
    Regulation of FZD by ubiquitination RNF43,FMNL3,RSPO1,RSPO2,LGR5,RSPO3,LGR4,ZNRF3,RSPO4

    Protein Function

    LGR6 has several biochemical functions, for example, NOT G-protein coupled receptor activity,protein binding,transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LGR6 itself. We selected most functions LGR6 had, and list some proteins which have the same functions with LGR6. You can find most of the proteins on our site.

    Function Related Protein
    protein binding ZP3,SLC22A17,EAF1,SGPL1,GNAI3,C1orf109,ICA1,KRT6B,ZFP36,CDK15
    transmembrane signaling receptor activity TLR9,TLR3,OR103-4,CD97,LILRB3, Cd79b,GIPR,EVI2A,CD300C,PTH1RA
    NOT G-protein coupled receptor activity LGR5,FRZB,SFRP1A,SZL,SFRP2,LGR4,SFRP4,SFRP1,SFRP1B

    Interacting Protein

    LGR6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LGR6 here. Most of them are supplied by our site. Hope this information will be useful for your research of LGR6.

    LGR6 Related Signal Pathway

    Resources

    References

    • Kitamura, J; Uemura, M; et al. Chronic Lung Injury by Constitutive Expression of Activation-Induced Cytidine Deaminase Leads to Focal Mucous Cell Metaplasia and Cancer. PLOS ONE 10:-(2015).
    • Ren, WW; Lewandowski, BC; et al. Single Lgr5- or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:16401-16406(2014).

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