LETM1
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Official Full Name
leucine zipper-EF-hand containing transmembrane protein 1 -
Overview
This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. -
Synonyms
LETM1;leucine zipper-EF-hand containing transmembrane protein 1;LETM1 and EF-hand domain-containing protein 1, mitochondrial;Mdm38 homolog (yeast);Mdm38 homolog;leucine zipper-EF-hand-containing transmembrane protein 1
Recombinant Proteins
- Human
- Chicken
- Rat
- Zebrafish
- Mouse
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Bovine
- zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
Involved Pathway
LETM1 involved in several pathways and played different roles in them. We selected most pathways LETM1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with LETM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
LETM1 has several biochemical functions, for example, calcium ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LETM1 itself. We selected most functions LETM1 had, and list some proteins which have the same functions with LETM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | S100Z,DSC2,CALUA,SPARC,ACTN1,MEX3B,CALM2,EFCAB2,MFGE8B,NCS1B |
| protein binding | ACTR1B,KRTAP19-7,GNG12,TRIM59,C11orf49,Raet1a,ITSN2,FLCN,RRAS2,GATA2 |
Interacting Protein
LETM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LETM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LETM1.
PSMA3;SGK1;MCC;BCS1L;1C;ICT1;P;Lats2;TBK1
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