LEF1

  • Official Full Name

    lymphoid enhancer-binding factor 1

  • Overview

    This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

  • Synonyms

    LEF1;lymphoid enhancer-binding factor 1;LEF-1;TCF10;TCF7L3;TCF1ALPHA;TCF1-alpha;T cell-specific transcription factor 1-alpha

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cell
  • HEK293
  • His
  • Non
  • GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
LEF1-540H Recombinant Human LEF1, His-tagged E.coli Human His 1-399aa
LEF1-166H Recombinant Human LEF1 protein, His-tagged E.coli Human His
LEF1-3373R Recombinant Rat LEF1 Protein Mammalian Cell Rat His
LEF1-6571C Recombinant Chicken LEF1 Mammalian Cell Chicken His
LEF1-8995Z Recombinant Zebrafish LEF1 Mammalian Cell Zebrafish His
LEF1-9035M Recombinant Mouse LEF1 Protein Mammalian Cell Mouse His
LEF1-4778HCL Recombinant Human LEF1 293 Cell Lysate HEK293 Human Non
LEF1-301549H Recombinant Human LEF1 protein, GST-tagged E.coli Human GST Met1-Asp98
LEF1-3029R Recombinant Rat LEF1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
LEF1-3029R-B Recombinant Rat LEF1 Protein Pre-coupled Magnetic Beads HEK293 Rat
LEF1-4817H Recombinant Human LEF1 Protein (Glu45-His260), N-His tagged E.coli Human His Glu45-His260
LEF1-5032M Recombinant Mouse LEF1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
LEF1-5032M-B Recombinant Mouse LEF1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    LEF1 involved in several pathways and played different roles in them. We selected most pathways LEF1 participated on our site, such as Wnt signaling pathway,Hippo signaling pathway,Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) LAMA2,ITGA10,DMD,GJA1,EMD,ITGA7,CACNA2D3,CACNA2D2,ACTN2,ITGA4
    Adherens junction TCF7L1A,CREBBP,SMAD3A,CTNNA1,PTBP3,ACTB,CDC42L2,PVRL4,RHOAC,PTPN1
    Wnt signaling pathway AXIN1,PPP3R1B,BTRC,CAMK2D,Fzd4,NLK1,PRKCA,TCF7,FZD9,SFRP4
    Pathways in cancer HSP90B1,FGF18,GNB1,CASP8,HSP90AB1,SLC2A1,CBLC,VEGFC,F2RL3,TRAF4
    Colorectal cancer MLH1,BCL2,CASP9,FOS,RHOA,SMAD4,TCF7L2,TGFB2,PIK3R2,APC
    Prostate Cancer AKT1,CPN1,NKX3-1,INS,NOXA1,CCNE2,KRAS,CREB5,ERBB2,PIK3R5
    Endometrial cancer BRAF,SOS1,PIK3R3,MAP2K2,ARAF,MAPK1,PIK3CG,BAD,AXIN2,MLH1
    Basal cell carcinoma FZD10,GLI3,FZD6,GSK3B,WNT6,WNT7A,PTCH1,PTCH2,AXIN2,FZD3
    Thyroid cancer NRAS,NCOA4,CDH1,TPM3,TP53,PAX8,TPR,TCF7L2,PPARG,NTRK1

    Protein Function

    LEF1 has several biochemical functions, for example, C2H2 zinc finger domain binding,DNA binding,DNA binding, bending. Some of the functions are cooperated with other proteins, some of the functions could acted by LEF1 itself. We selected most functions LEF1 had, and list some proteins which have the same functions with LEF1. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding POT1A,ZBTB20,UPF1,STRA13,RXRA,ASH2L,HIST2H2L,ZNF560,TMEM18,NKX2-6
    sequence-specific DNA binding HOXD10A,NR2F6B,DMRT2B,RARAB,HOXC4,NKX2.4A,NKX2,FOXF2,NKX2.5,GRHL1
    gamma-catenin binding PTPRK,APC,PTBP3,PTPRJ,APC2,CDH2,TCF7L2,CDH1,FER,CTNNA1
    armadillo repeat domain binding STRN,CALCOCO1,AXIN2,TCF7L2,AXIN1,CNOT1,STRN4,CHD8,CTNNBIP1
    protein binding NFASC,EIF3L,OTULIN,MEIS1B,EMP3,STAT5A,COL6A2,FCNA,DDX18,ACP1
    transcription factor binding SOST,DIP2BA,HYAL1,ATF7,BCL2,SRY,TWIST1,TCF3,CDKN2A,RB1
    estrogen receptor activity NKX3,ESR2,ESR2B,ESR2A,GPR30,NKX3-1,ESR1
    transcription factor activity, sequence-specific DNA binding RORCB,MTF1,ONECUT3,SLAMF7,STAT4,ESRRGB,Ar,ATOH8,E2F6,PPARA
    enhancer binding SMAD3,ELL3,RAI1,AHR,TCF12,TIPARP,SP1,SOX9,TCF3,FOXH1

    Interacting Protein

    LEF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEF1.

    CTNNB1;IGF1R;TLE1;7242199;Hdac1;AURKA;BUB1;NRAS;RB1;MLH1;MSH2;BAX

    Resources

    Research Area

    Wnt Signaling Modulators
    Transcription Factors in the Akt Pathway

    References

    • Lee, JM; Miyazawa, S; et al. Shh signaling is essential for rugae morphogenesis in mice. HISTOCHEMISTRY AND CELL BIOLOGY 136:663-675(2011).
    • Koizumi, Y; Kawashima, N; et al. Wnt11 expression in rat dental pulp and promotional effects of Wnt signaling on odontoblast differentiation. CONGENITAL ANOMALIES 53:101-108(2013).

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