LECT1
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Official Full Name
leukocyte cell derived chemotaxin 1 -
Overview
This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
LECT1;leukocyte cell derived chemotaxin 1;multiple myeloma tumor suppressor 1 , MYETS1;leukocyte cell-derived chemotaxin 1;CHM I;CHM1;chondromodulin;Chondromodulin I;BRICD3;BRICHOS domain containing 3;Chondrosurfactant protein;LECT 1;chondromodulin-1;chondromodulin-I;OTTHUMP00000018466;OTTHUMP00000235443;multiple myeloma tumor suppressor 1;CHM-I;MYETS1
Recombinant Proteins
- Human
- Rat
- Chicken
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Non
- His
- Fc
- His&Fc&Avi
- His&SUMO
Involved Pathway
LECT1 involved in several pathways and played different roles in them. We selected most pathways LECT1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with LECT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
LECT1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by LECT1 itself. We selected most functions LECT1 had, and list some proteins which have the same functions with LECT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
LECT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LECT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LECT1.
MYC;APOA1
Resources
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References
- Li, CH; Lu, XJ; et al. Passive protective effect of chicken egg yolk immunoglobulins against experimental Vibrio anguillarum infection in ayu (Plecoglossus altivelis). FISH & SHELLFISH IMMUNOLOGY 37:108-114(2014).
- Okumura, A; Saito, T; et al. Suppressive role of leukocyte cell-derived chernotaxin 2 in mouse anti-type II collagen antibody-induced arthritis. ARTHRITIS AND RHEUMATISM 58:413-421(2008).
