LCOR
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Official Full Name
ligand dependent nuclear receptor corepressor -
Overview
LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound;nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al.,;2003 (PubMed 12535528)). -
Synonyms
LCOR;ligand dependent nuclear receptor corepressor;ligand-dependent corepressor;FLJ38026;KIAA1795;MLR2;A630025C20RIK;LCOR_HUMAN;Ligand dependent corepressor;Mblk1 related protein 2;Mblk1-related protein 2;RP11 175O19.1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LCOR-527H | Recombinant Human LCOR, GST-tagged | E.coli | Human | GST | 1-406aa | |
| LCOR-4929Z | Recombinant Zebrafish LCOR | Mammalian Cell | Zebrafish | His |
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| LCOR-976HCL | Recombinant Human LCOR cell lysate | Human | Non |
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| LCOR-5396H | Recombinant Human LCOR Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
LCOR involved in several pathways and played different roles in them. We selected most pathways LCOR participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with LCOR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
LCOR has several biochemical functions, for example, DNA binding,protein binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LCOR itself. We selected most functions LCOR had, and list some proteins which have the same functions with LCOR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | FOXF2,HOXD4A,TAF6,ZBED5,ZBTB37,PAX7A,NKX2-6,ZNF83,CERS5,TFIP11 |
| transcription factor activity, sequence-specific DNA binding | GCM2,WNT5A,RXRBB,ZNF71,TEAD2,UBN2B,ZNF239,PHTF1,IKZF5,FOXA |
| protein binding | PROM1,SUMO2,MPRIP,STX3,MRPS31,BECN1,CNO,TBRG4,GRIA2,KLRC4-KLRK1 |
| transcription factor binding | PBX1,KAT6B,NKX2,DRAP1,KEAP1B,PARP1,VDRA,ENPP2,ESRRB,NAB2 |
Interacting Protein
LCOR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LCOR here. Most of them are supplied by our site. Hope this information will be useful for your research of LCOR.
CTBP2;GOLGA2;TRAF1;CTBP2
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References
- Widerak, M; Ghoneim, C; et al. The aryl hydrocarbon receptor activates the retinoic acid receptor alpha through SMRT antagonism. BIOCHIMIE 88:387-397(2006).
- Chien, PY; Ito, M; et al. A fusion protein of the estrogen receptor (ER) and nuclear receptor corepressor (NCoR) strongly inhibits estrogen-dependent responses in breast cancer cells. MOLECULAR ENDOCRINOLOGY 13:2122-2136(1999).
- Boutell, JM; Thomas, P; et al. Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin. HUMAN MOLECULAR GENETICS 8:1647-1655(1999).
