LCMT2
-
Official Full Name
leucine carboxyl methyltransferase 2 -
Overview
The protein encoded by this intronless gene belongs to the highly variable methyltransferase superfamily. This gene is the inferred homolog of the Saccharomyces cerevisiae carboxymethyltransferase gene PPM2 that is essential for the synthesis of the hypermodified guanosine Wybutosine (yW). -
Synonyms
LCMT2;leucine carboxyl methyltransferase 2;KIAA0547;MGC9534;PPM2;tRNA yW synthesizing protein 4;TYW4;tRNA-yW synthesizing protein 4;tRNA-Wybutosine-synthesizing protein 4;p21WAF1/CIP1 promoter-interacting protein;FLJ51321
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- HEK293
- Insect Cell
- Mammalian Cell
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
LCMT2 involved in several pathways and played different roles in them. We selected most pathways LCMT2 participated on our site, such as Gene Expression,Synthesis of wybutosine at G37 of tRNA(Phe),tRNA modification in the nucleus and cytosol, which may be useful for your reference. Also, other proteins which involved in the same pathway with LCMT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| tRNA modification in the nucleus and cytosol | TYW5,OSGEP,CDKAL1,NSUN2,THG1L,LBH,KIAA1456,CCDC76,ADAT3,TRMT44 |
| wybutosine biosynthesis | TYW3,TYW1 |
| tRNA processing | CDKAL1,TSEN54,ADAT1,TRDMT1,TSEN2,TP53RK,ADAT2,C2orf49,QTRTD1,RPP14 |
| Gene Expression | SAP30BP,ZNF434,SF3A1,NR2F1A,MED20,SUZ12B,ZNF445,SLBP,ZNF224,IGF2BP1 |
| Synthesis of wybutosine at G37 of tRNA(Phe) | TYW5,TRMT12,TYW3,TRMT5,TYW1 |
Protein Function
LCMT2 has several biochemical functions, for example, S-adenosylmethionine-dependent methyltransferase activity,protein binding,tRNA methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LCMT2 itself. We selected most functions LCMT2 had, and list some proteins which have the same functions with LCMT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tRNA methyltransferase activity | TRDMT1,PRDM11,PRDM12,TRMT10C,DIMT1,PRDM13,PRMT8B,METTL8,CCDC76,TRMT13 |
| protein binding | BRIP1,TRP63,XK,C1orf38,HMGA1,HOMER3,GOLGA8G,PI4KB,ESR1,P2RY6 |
| S-adenosylmethionine-dependent methyltransferase activity | C6orf211,METTL7A,LSM1,RRP8,TPMT.2,LCMT1,PRMT7,COQ5,PRMT8B,WBSCR27 |
Interacting Protein
LCMT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LCMT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LCMT2.
AP4M1;VPS26A;SNCA;Ctnnbl1
Resources
Related Services
Related Products
References
- Kalhor, HR; Luk, K; et al. Protein phosphatase methyltransferase 1 (Ppm1p) is the sole activity responsible for modification of the major forms of protein phosphatase 2A in yeast. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 395:239-245(2001).
