LCK
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Official Full Name
lymphocyte-specific protein tyrosine kinase -
Overview
Lck is a 56 kD tyrosine protein kinase and a member of the src subfamily that contains both an SH2 and SH3 domain. Alternatively spliced isoforms of Lck have been reported. Lck is a cytoplasmic protein bound to CD4 and CD8 in T lymphocytes that participat -
Synonyms
LCK;lymphocyte-specific protein tyrosine kinase;tyrosine-protein kinase Lck;leukocyte C-terminal Src kinase;p56(LSTRA) protein-tyrosine kinase;t cell-specific protein-tyrosine kinase;proto-oncogene tyrosine-protein kinase LCK;lymphocyte cell-specif
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- S.frugiperda
- Insect Cell
- Sf9 Insect Cell
- Mammalian Cell
- HEK293
- HEK293T
- Mamanlian cells
- Insect (sf21)
- GST
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
- His&SUMO
Involved Pathway
LCK involved in several pathways and played different roles in them. We selected most pathways LCK participated on our site, such as NF-kappa B signaling pathway,Osteoclast differentiation,Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with LCK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NF-kappa B signaling pathway | CCL4L2,CCL4,MAP3K7,CCL21B,CCL4L1,IRAK1,GADD45B,BCL10,Ccl21a,TNF |
| Osteoclast differentiation | FHL2,SIRP-BETA,PLCG2,TGFBR1,PPARG,LILRA4,PIK3CD,IFNB1,MAP2K6,PPP3CA |
| T cell receptor signaling pathway | NFKBIB,PIK3R3,MAPK13,MUC1,CD8B,CARD11,RELA,TEC,DBNLB,PIK3R1 |
| Natural killer cell mediated cytotoxicity | KLRD1,IFNGR2,IFNA17,PTPN11,IFNA7,ICAM2,TNFRSF10C,Raet1c,HCST,BID |
| HTLV-I infection | NFKB1,HLA-DRB3,ATF3,HLA-DPA1,WNT2,BAX,NRAS,APC2,WNT6,EGR2 |
| nodeficiency | RFXANK,IKBKG,CD8B,BLNK,CD8B1,UNG,AICDA,RFXAP,CD3E,TNFRSF13B |
| Primary i | ORAI1,CD3E,CD19,TNFRSF13B,DCLRE1C,IGLL1,RAG2,RAG1,ZAP70,TAP2 |
Protein Function
LCK has several biochemical functions, for example, ATP binding,ATPase binding,CD4 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LCK itself. We selected most functions LCK had, and list some proteins which have the same functions with LCK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine phosphatase activity | PPM1E,CDC14B,PPP5C,PPM1BA,PPP3CA,PPM1AA,PPM1G,PDP1,CTDNEP1,MTMR4 |
| protein tyrosine kinase activity | ABL2,SYK,FGFR3,NEK1,KITA,IGF1R,FGFR2,FES,ALK,ERBB3B |
| protein complex binding | PEX26,MAPK8IP2,ABI1,THRA,CALCA,RAP1A,UGT1A6B,CAV3,PROS1,CEBPA |
| glycoprotein binding | FLNA,ITGAM,FOXRED2,CALR,RGMA,BBC3,APOH,LMAN2,ACE2,ITGA3 |
| protein phosphatase binding | EGFR,PPP1R3G,CDH2,MET,ITPR1,JUPA,SNX3,MAPK14,DLG3,SKAP1 |
| protein kinase binding | FAM83E,SHC1,SPAG16,ZC3HC1,CDC42,USP37,PTPRC,SCN5A,FER,TBL2 |
| ATP binding | MAPK3,UCK2B,DDX5,MAP4K5,FGFR1,VARS2,CKMT2A,GTF2F2,RIMKLA,NOL9 |
| CD8 receptor binding | FYN |
| CD4 receptor binding | SPG21,FYN,PLSCR4,PLSCR1 |
Interacting Protein
LCK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LCK here. Most of them are supplied by our site. Hope this information will be useful for your research of LCK.
PTPRC;KHDRBS1;tip_shv2c
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References
- Chang, CH; Wang, Y; et al. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells. MABS 7:199-211(2015).
- Guo, N; Zhang, K; et al. CD147 and CD98 complex-mediated homotypic aggregation attenuates the CypA-induced chemotactic effect on Jurkat T cells. MOLECULAR IMMUNOLOGY 63:253-263(2015).
