LAMC2
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Official Full Name
laminin, gamma 2 -
Overview
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms, which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. -
Synonyms
LAMC2;laminin, gamma 2;B2T;CSF;EBR2;BM600;EBR2A;LAMB2T;LAMNB2;laminin subunit gamma-2;BM600-100kDa;laminin B2t chain;CSF 140 kDa subunit;nicein subunit gamma;kalinin subunit gamma;ladsin 140 kDa subunit;epiligrin subunit gamma;cell-scattering factor 140 kDa subunit;large adhesive scatter factor 140 kDa subunit
Recombinant Proteins
- Human
- Mouse
- Rat
- HEK293
- HEK293T
- Mammalian cells
- E.coli
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
- His
- His&GST
- His&GST&Myc
Involved Pathway
LAMC2 involved in several pathways and played different roles in them. We selected most pathways LAMC2 participated on our site, such as PIK-Akt signaling pathway,Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAMC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | PKN3,G6PC2,GNG12,FLT4,DDIT4,Il4ra,EPO,PKN1,IFNA16,PDGFC |
| Small cell lung cancer | PTGS2,BCL2,TRAF1,BCL2L1,TRAF2,LAMA2,TP53,LAMB2,PIK3CA,TRAF4 |
| Amoebiasis | LAMA1,GNA15,GM-CSF,RELA,PIK3CG,RAB7,SERPINB3C,SERPINB1C,PLCB1,C8A |
| ECM-receptor interaction | COL11A1A,COL6A1,COL1A1,TNN,SV2C,THBS4,TNR,CD47,ITGA3,ITGB3B |
| Toxoplasmosis | BAD,TAB2,PIK3R3,H2-AB1,LAMA3,Casp3,LAMA2,ITGB1,LAMB3,PIK3CA |
| Pathways in cancer | MMP1,GNGT1,BRAF,Adcy4,GNB1,ROCK2,PRKACA,RARA,FGF14,RXRG |
| Focal adhesion | VEGFAA,VAV2,CDC42L2,PPP1CBL,PRKCB,PIK3R5,VAV3,RAC3B,PXNA,RAC1B |
Protein Function
LAMC2 has several biochemical functions, for example, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LAMC2 itself. We selected most functions LAMC2 had, and list some proteins which have the same functions with LAMC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heparin binding | CCL15,SMOC2,SELP,VEGFAB,PCOLCE2,PTN,FGFR1,FGF10,CXCL11,HSD17B12 |
Interacting Protein
LAMC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAMC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LAMC2.
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References
- Garg, M; Kanojia, D; et al. Laminin-5 gamma-2 (LAMC2) Is Highly Expressed in Anaplastic Thyroid Carcinoma and Is Associated With Tumor Progression, Migration, and Invasion by Modulating Signaling of EGFR. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99:E62-E72(2014).
- Yuen, WY; Lemmink, HH; et al. Herlitz junctional epidermolysis bullosa: diagnostic features, mutational profile, incidence and population carrier frequency in the Netherlands. BRITISH JOURNAL OF DERMATOLOGY 165:1314-1322(2011).
