Kitl
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Official Full Name
kit ligand -
Overview
Murine SCF or Stem Cell Factor, also known as Kit Ligand, is a 273 amino acid cytokine protein expressed from the Kitl gene located on chromosome 10. After initial synthesis and translocation, the 25 residue signal sequence is cleaved, allowing for the 248 residue SCF to properly fold and mature. If the SCF or Kit Ligand is cleaved again on the C- terminal end at residue 190, then the soluble Kit Ligand is formed. SCF, a non-covalently linked homodimer, is known to stimulate the proliferation of mast cells and is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Also, SCF serves to mediate cell-cell adhesion and acts synergistically with other cytokines and interleukins. -
Synonyms
Clo;Con;Gb;Kitlg;Mgf;SCF;SF;SLF;Sl;contrasted;C-kit ligand;Steel factor;cloud gray;grizzle-belly;hematopoietic growth factor KL;mast cell growth factor;stem cell factor Location: 10 51.4 cM
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Kitl-575M | Active Recombinant Mouse Kitl protein(Met1-Ala189), His-tagged | Insect Cells | Mouse | His | Met1-Ala189 | |
| Kitl-576M | Active Recombinant Mouse Kitl protein, His-tagged | HEK293 | Mouse | His | Lys 26 - Ala 189 |
|
| KITL-524M | Recombinant Mouse KITL Protein, Biotinylated | Mouse | 273 |
|
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| KITL-526M | Recombinant Mouse KITL Protein | Mouse | 273 |
|
Involved Pathway
Kitl involved in several pathways and played different roles in them. We selected most pathways Kitl participated on our site, such as Ras signaling pathway,Rap signaling pathway,Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with Kitl were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hematopoietic cell lineage | GP9,ITGA6,GM13305,GP1BB,CSF3,IL11RA,CD59A,CD3D,ITGB3,IL6 |
| Melanogenesis | CAMK2G1,Fzd4,a,MITFB,ADCY2B,TCF7L1A,GNA15.1,PRKACAA,WNT5B,PLCB1 |
| Pathways in cancer | GNAQ,FLT3,BMP4,NKX3,GNAI1,BRAF,PPARG,GNG12,WNT7B,SMAD4 |
| Phospholipase D signaling pathway | MTOR,IL-8,MAPK1,PLA2G4C,LPAR6,GRM1,CYTH1,AKT2,RHEB,PLCB1 |
| Ras signaling pathway | RASGRP3,FGF22,CALM1,LOC608458,GNG7,PGF,ETS1,CALM4,GNG5,PLA2G4F |
| Rap signaling pathway | MAPK11,LPAR4,RAC2,KIT,Itgam&Itgb2,FIGF,MET,VASP,ITGA2B,VEGFA |
| Cytokine-cytokine receptor interaction | Cxcl15,IL9R,IL24,BMP7A,CSF2RB,CXCL8B.3,TNFRSF12A,FIGF,TNFSF10,IL7R |
| PIK-Akt signaling pathway | VEGFB,PPP2R2D,IFNA10,PIK3CA,TCL1B,ITGB8,PCK1,GRB2,TCL1A,LAMA1 |
Protein Function
Kitl has several biochemical functions, for example, cytokine activity,growth factor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Kitl itself. We selected most functions Kitl had, and list some proteins which have the same functions with Kitl. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| stem cell factor receptor binding | KITLGA,SPRED1,KITLG,KITLGB,SPRED2 |
| cytokine activity | IL29,TNFSF18,IL20,LFT1,IL1B,IL22,CMTM8,IL34,HMGB1A,IL11 |
| growth factor activity | MIA1,PDGFA,GDF15,FGF4,MDKB,SPAW,FGF20,WISP3,FGF8B,BMP8B |
| protein binding | NOS1,NUDT12,ARHGEF4,PTPRZ1,KRAS,AKAP9,SLC6A12,AMOTL2A,SIAH1,TNNI1 |
Interacting Protein
Kitl has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Kitl here. Most of them are supplied by our site. Hope this information will be useful for your research of Kitl.
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References
- Tabone-Eglinger, S; Calderin-Sollet, Z; et al. Niche anchorage and signaling through membrane-bound Kit-ligand/c-kit receptor are kinase independent and imatinib insensitive. FASEB JOURNAL 28:4441-4456(2014).
- Olgasi, C; Dentelli, P; et al. DNA vaccination against membrane-bound Kit ligand: A new approach to inhibiting tumour growth and angiogenesis. EUROPEAN JOURNAL OF CANCER 50:234-246(2014).
