Kcnn2
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Official Full Name
Kcnn2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 -
Synonyms
KCNN2;potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2;small conductance calcium-activated potassium channel protein 2;SKCa 2;small conductance calcium-activated potassium channel subfamily N member 2;SK2;fri;SKCA2;KCa2.2
Recombinant Proteins
- Rat
- Chicken
- Mouse
- Human
- Mus musculus
- Mammalian Cell
- In vitro E. coli expression system
- E.coli
- HEK293
- E.coli expression system
- His
- His&Fc&Avi
Involved Pathway
Kcnn2 involved in several pathways and played different roles in them. We selected most pathways Kcnn2 participated on our site, such as BDNF signaling pathway,Bile secretion,Ca2+ activated K+ channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with Kcnn2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Potassium Channels | KCNS2,KCNK7,KCNV2,KCNA7,KCNJ1,KCNC3A,KCNA1,KCNJ8,KCNA6A,KCNG3 |
| Neuronal System | KCNQ3,KCNK13B,KCNA7,KCNJ11,CPLX2L,KCNF1A,MYO6,KCNS3,Apba1,KCNN4 |
| Serotonergic synapse | HTR3C,HTR1E,HTR5A,HRAS,GNG5,CYP2J6,ALOX12B,GABRB1,CYP2C50,PTGS2 |
| Ca2+ activated K+ channels | KCNMA1,KCNN1A,KCNMB2,KCNMB1,KCNN3,KCNN1B,KCNN1,KCNN4 |
| Insulin secretion | GCG,Adcy4,PLCB3,KCNN4,FFAR1,CCKAR,ATP1A1,RAB3A,GNAQ,GLP1R |
| Bile secretion | RXRA,AQP8,ATP1B4,ABCB1,Adcy4,FAM84B,SLC22A8,Car2,ABCC2,SLC22A1 |
| BDNF signaling pathway | EIF4EBP1,EIF4E,EGR1,FRS2,CDH2,YBX1,CSNK2A1,EIF2S1,JAK2,CFL1 |
Protein Function
Kcnn2 has several biochemical functions, for example, alpha-actinin binding,calcium-activated potassium channel activity,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Kcnn2 itself. We selected most functions Kcnn2 had, and list some proteins which have the same functions with Kcnn2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alpha-actinin binding | MYOT,RARA,KCNA5,DAG1,ADORA2A,ALMS1,XIRP2,PKD2L1,MAGI1,LRRC10 |
| small conductance calcium-activated potassium channel activity | KCNN1,KCNN1B,KCNN3,KCNN1A |
| calmodulin binding | TRPV4,CAMKK2,STRN,PHKB,ADD3,SLC9A1,NETO2,NRGN,ADCY1,MYLK |
| protein homodimerization activity | CAMK2D,PLD6,TCF4,ANG,CAV2,CCDC103,CALCOCO2,SRM,NR0B2,UXS1 |
| protein domain specific binding | CNTROB,GSN,HIST1H4B,ESRRA,WNT1,STX1A,YWHAQA,ACSL3,TNFAIP1,CNTLN |
| calcium-activated potassium channel activity | KCNMA1,KCNK18,KCNMB2,HPN,KCNN4,KCNMB3,KCNN1B,CCT8L2,MTMR6,KCNT1 |
Interacting Protein
Kcnn2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Kcnn2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Kcnn2.
SRPK2;SRPK1
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References
- Kim, JJ; Park, YM; et al. Identification of KCNN2 as a susceptibility locus for coronary artery aneurysms in Kawasaki disease using genome-wide association analysis. JOURNAL OF HUMAN GENETICS 58:521-525(2013).
- Chang, SH; Chang, SN; et al. Significant Association of rs13376333 in KCNN3 on Chromosome 1q21 With Atrial Fibrillation in a Taiwanese Population. CIRCULATION JOURNAL 76:184-188(2012).
- Li, C; Wang, F; et al. Significant association of SNP rs2106261 in the ZFHX3 gene with atrial fibrillation in a Chinese Han GeneID population. HUMAN GENETICS 129:239-246(2011).
- Mauler, F; Hinz, V; et al. Selective intermediate-/small-conductance calcium-activated potassium channel (KCNN4) blockers are potent and effective therapeutics in experimental brain oedema and traumatic brain injury caused by acute subdural haematoma. EUROPEAN JOURNAL OF NEUROSCIENCE 20:1761-1768(2004).
