KPNA3
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Official Full Name
karyopherin alpha 3 (importin alpha 4) -
Overview
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. -
Synonyms
KPNA3;karyopherin alpha 3 (importin alpha 4);importin subunit alpha-3;hSRP1;IPOA4;SRP1gamma;SRP4;SRP1 gamma;IMA3_HUMAN;Importin alpha 3;Importin alpha 3 subunit;Importin alpha 4;Importin alpha Q2;Karyopherin alpha 3;Karyopherin alpha 3 importin alpha 4;Karyopherin alpha 3 subunit;Karyopherin subunit alpha 3;Karyopherin subunit alpha-3;KPNA 3;Qip2;SRP1;SRP1-gamma;importin alpha-3;importin-alpha-Q2;OTTHUMP00000018426
Recombinant Proteins
- Zebrafish
- Human
- Chicken
- Mouse
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- HEK293T
- His
- Non
- His&T7
- Myc&DDK
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KPNA3-11467Z | Recombinant Zebrafish KPNA3 | Mammalian Cell | Zebrafish | His |
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| KPNA3-29810TH | Recombinant Human KPNA3 | Wheat Germ | Human | Non | 100 amino acids |
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| KPNA3-4115C | Recombinant Chicken KPNA3 | Mammalian Cell | Chicken | His |
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| KPNA3-7882H | Recombinant Human KPNA3 protein, His & T7-tagged | E.coli | Human | His&T7 | Glu3~Val220 |
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| KPNA3-8799M | Recombinant Mouse KPNA3 Protein | Mammalian Cell | Mouse | His |
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| KPNA3-4890HCL | Recombinant Human KPNA3 293 Cell Lysate | HEK293 | Human | Non |
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| Kpna3-1280M | Recombinant Mouse Kpna3 Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| KPNA3-4895H | Recombinant Human KPNA3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| KPNA3-4897M | Recombinant Mouse KPNA3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| KPNA3-4897M-B | Recombinant Mouse KPNA3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
KPNA3 involved in several pathways and played different roles in them. We selected most pathways KPNA3 participated on our site, such as Antiviral mechanism by IFN-stimulated genes,Cytokine Signaling in Immune system,Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with KPNA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Infectious disease | NMT2,STX1B,PPIAL4A,VPS37A,AP1S1,KPNA4,LTF,CPSF4,RCC1,CHMP4B |
| Immune System | CRCP,DCTN3,HAVCR2,SIGLEC6,TXNIPB,EGR1,KIR2DS2,LRSAM1,KIF3B,FAM49BA |
| Host Interactions with Influenza Factors | CPSF4,KPNA5,KPNA4 |
| Antiviral mechanism by IFN-stimulated genes | DPF1,EIF4G2,JAK1,UBE2L6,IFIT8,NUPL2,NUP35,EIF4G2A,MX2,EIF4G1 |
| Influenza Infection | KPNA4,KPNA5,IPO5,CPSF4 |
| Disease | ANTXR2,OS9,TNKS,CPSF6,NUP50,NMT1,AP2M1,CHMP4B,DPF1,GYG1 |
| ISG15 antiviral mechanism | IFIT12,EIF4E3,UBE2L6,KPNA5,MX2,USP18,ARIH1,EIF4G2,HERC5,IFIT10 |
| Cytokine Signaling in Immune system | IRF4,EIF4G2A,CSF2RB,IFIT8,MX2,TRIM45,FGF20A,NRG2A,SPTB,HLA-DQB2 |
Protein Function
KPNA3 has several biochemical functions, for example, nuclear localization sequence binding,protein C-terminus binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KPNA3 itself. We selected most functions KPNA3 had, and list some proteins which have the same functions with KPNA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein C-terminus binding | XRCC5,KCNK3,HSPG2,MKI67,AGO2,PPP2CA,JAK2,MSH2,HOMER3,ERCC4 |
| nuclear localization sequence binding | NUP214,KPNB3,KPNB1,NFKBIA,KPNA7,TNPO1,BRAP,IPO5,TNPO3,KPNA1 |
| protein transporter activity | XPO6,CHMP7,EIF4ENIF1,AP1S3B,COX18,COG3,AP4B1,RAB4A,XPO1,CALCR |
| protein binding | Reln,TDG,PKD1L3,ETV7,OSBPL6,FZD10,SUGT1,APEX1,PIP5K1A,RAB14 |
Interacting Protein
KPNA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KPNA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KPNA3.
CDKN1B;KPNB1;Ranbp2;Mkl1;CBX5
Resources
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References
- Ben-Efraim, I; Frosst, PD; et al. Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein Tpr. BMC CELL BIOLOGY 10:-(2009).
