KLRC4
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Official Full Name
killer cell lectin-like receptor subfamily C, member 4 -
Overview
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member 1) family member. -
Synonyms
KLRC4;killer cell lectin-like receptor subfamily C, member 4;NKG2-F type II integral membrane protein;NKG2 F;NK cell receptor F;NKG2-F-activating NK receptor;NKG2F;NKG2F_HUMAN;natual killer cell group 2-F;NKG2-F
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KLRC4-4894HCL | Recombinant Human KLRC4 293 Cell Lysate | HEK293 | Human | Non |
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| KLRC4-4912H | Recombinant Human KLRC4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| KLRC4-5907HF | Recombinant Full Length Human KLRC4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 158 amino acids |
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| RFL14264HF | Recombinant Full Length Human Nkg2-F Type Ii Integral Membrane Protein(Klrc4) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length (1-158) |
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Involved Pathway
KLRC4 involved in several pathways and played different roles in them. We selected most pathways KLRC4 participated on our site, such as Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLRC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing and presentation | HLA-DPB1,PDIA3,TAP2,CD74,HSPA6,HSPA8,RFX5,NFYB,KLRD1,HLA-DRB5 |
Protein Function
KLRC4 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by KLRC4 itself. We selected most functions KLRC4 had, and list some proteins which have the same functions with KLRC4. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
KLRC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLRC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLRC4.
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References
- Carmona, FD; Martin, J; et al. Genetics of vasculitis. CURRENT OPINION IN RHEUMATOLOGY 27:10-17(2015).
