KLF8
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Official Full Name
Kruppel-like factor 8 -
Overview
This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. -
Synonyms
KLF8;Kruppel-like factor 8;Krueppel-like factor 8;BKLF3;DXS741;ZNF741;Basic krueppel-like factor 3;Kruppel like factor 8;MGC138314;Zinc finger protein 741;basic kruppel-like factor 3
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KLF8-940HCL | Recombinant Human KLF8 cell lysate | Human | Non |
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| KLF8-301536H | Recombinant Human KLF8 protein, GST-tagged | E.coli | Human | GST | Gly207-Val284 |
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Involved Pathway
KLF8 involved in several pathways and played different roles in them. We selected most pathways KLF8 participated on our site, such as Signaling events mediated by focal adhesion kinase, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling events mediated by focal adhesion kinase | ARHGEF28,ARHGAP26,BMX,ACTA1 |
Protein Function
KLF8 has several biochemical functions, for example, DNA binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLF8 itself. We selected most functions KLF8 had, and list some proteins which have the same functions with KLF8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | POLR2J,FOXE3,PPARGC1A,ZFP382,MCM3AP,MYC,HIST2H2BB,ZNF615,ZNF471,IER2 |
| metal ion binding | NMRK2,PLAG1,Scd2,EFCAB5,ZFP27,PC,ZNF576.2,RNF149,MOBKL2A,MARCH4 |
Interacting Protein
KLF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLF8.
Dlg4;b4dms2_human;BIN1;MICALL1;DGCR8;ANTXR1
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References
- Teylaert, B; Meurice, E; et al. Molecular cloning, characterization, genomic organization and promoter analysis of the alpha 1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0. BMC BIOTECHNOLOGY 11:-(2011).
- Lee, J; Lee, J; et al. Ultraviolet A Regulates Adipogenic Differentiation of Human Adipose Tissue-derived Mesenchymal Stem Cells via Up-regulation of Kruppel-like Factor 2. JOURNAL OF BIOLOGICAL CHEMISTRY 285:32647-32656(2010).
- Panigada, M; Porcellini, S; et al. GKLF in thymus epithelium as a developmentally regulated element of thymocyte-stroma cross-talk. MECHANISMS OF DEVELOPMENT 81:103-113(1999).
