KIR2DL4
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Official Full Name
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 -
Overview
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants. -
Synonyms
KIR2DL4;killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4;killer cell immunoglobulin-like receptor 2DL4;15.212;103AS;CD158D;KIR-103AS;NK cell receptor;killer Ig receptor;CD158 antigen-like family member D;MHC class
Recombinant Proteins
- Human
- E.coli
- HEK293
- CHO
- Human Cells
- Mammalian cells
- Non
- His
- Fc
Involved Pathway
KIR2DL4 involved in several pathways and played different roles in them. We selected most pathways KIR2DL4 participated on our site, such as Antigen processing and presentation,Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIR2DL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing and presentation | CD8B,HSP90AB1,CTSS,KIR2DS3,RFX5,HLA-DPB1,CALR,RFXANK,TAP1,NFYA |
| Natural killer cell mediated cytotoxicity | TYROBP,KIR3DL1,NCR1,GZMB,CD244,FASLG,IFNB1,FCER1G,KLRA8,FCGR3B |
Protein Function
KIR2DL4 has several biochemical functions, for example, protein binding,transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KIR2DL4 itself. We selected most functions KIR2DL4 had, and list some proteins which have the same functions with KIR2DL4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | BCS1L,NANOS3,UBQLN4,NCOR1,CCDC28A,IFT43,SEMA3E,PPP4R2,GNA13,HSPB2 |
| transmembrane signaling receptor activity | CD300C,AGER,FZD1,HIST2H3C2,ERBB2,GHRHR2,CD3D,OR12D2,TLR4,DCC |
Interacting Protein
KIR2DL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIR2DL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KIR2DL4.
TRIP6;RBPMS
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References
- Liu, XB; Zhao, MD; et al. Toxoplasma gondii Infection of Decidual CD1c(+) Dendritic Cells Enhances Cytotoxicity of Decidual Natural Killer Cells. INFLAMMATION 37:1261-1270(2014).
- Rajagopalan, S; Moyle, MW; et al. DNA-PKcs Controls an Endosomal Signaling Pathway for a Proinflammatory Response by Natural Killer Cells. SCIENCE SIGNALING 3:-(2010).
