KEAP1
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Official Full Name
kelch-like ECH-associated protein 1 -
Overview
The nuclear factor-like 2 (NRF2) transcriptional activator binds antioxidant response elements (ARE) of target gene promoter regions to regulate expression of oxidative stress response genes. Under basal conditions, the NRF2 inhibitor INrf2 (also called K -
Synonyms
KEAP1;kelch-like ECH-associated protein 1;INrf2;KIAA0132;KLHL19;MGC1114;MGC4407;MGC9454;MGC10630;MGC20887;kelch-like protein 19;cytosolic inhibitor of Nrf2
Recombinant Proteins
- Human
- Rat
- Mouse
- Insect Cells
- E.coli
- Insect Cell
- Mammalian Cell
- HEK293
- Wheat Germ
- E. coli
- Yeast
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- His&GST&Avi
- His
- His&Fc
- Myc&DDK
- GST
- Non
- His&T7
- His&GST
- His&Fc&Avi
- His&SUMO
- Flag
Involved Pathway
KEAP1 involved in several pathways and played different roles in them. We selected most pathways KEAP1 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with KEAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | CUL3,FBXW7,DET1,NEDD4,PIAS4A,SYVN1,UBA1,SMURF2,UBE2Z,CDC16 |
Protein Function
KEAP1 has several biochemical functions, for example, protein binding,transcription factor binding,contributes_to ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KEAP1 itself. We selected most functions KEAP1 had, and list some proteins which have the same functions with KEAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZKSCAN4,MCM6,REV1,BAP1,SH3GLB2,MEOX1,HIST1H4F,NECAB3,NCOA2,GTF2B |
| contributes_to ubiquitin-protein transferase activity | TCEB1,KLHL2,PHOSPHO2-KLHL23,KCTD10,KLHL10,FBXL15,BCOR,KBTBD10,KLHL5,KLHL23 |
| transcription factor binding | PITX2,CDKN2A,SUFU,DACT2,PDX1,WWP2,JUNB,KCTD1,HES2,TAF12 |
Interacting Protein
KEAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KEAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KEAP1.
SQSTM1;ETF1;NFE2L2
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References
- Cui, GZ; Luk, SCW; et al. Cytoprotection of Baicalein Against Oxidative Stress-induced Cardiomyocytes Injury Through the Nrf2/Keap1 Pathway. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 65:39-46(2015).
- Murakami, A; et al. Mechanisms Underlying Physiological Functions of Food Factors via Non-specific Interactions with Biological Proteins. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 135:47-55(2015).
