KDM5C
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Official Full Name
lysine (K)-specific demethylase 5C -
Overview
This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009] -
Synonyms
KDM5C;lysine (K)-specific demethylase 5C;MRXJ;SMCX;MRX13;MRXSJ;XE169;MRXSCJ;JARID1C;DXS1272E;lysine-specific demethylase 5C;protein SmcX;selected cDNA on X;Smcy homolog, X-linked;Smcx homolog, X chromosome;histone demethylase JARID1C;mental retardation, X-linked 13;JmjC domain-containing protein SMCX;Jumonji/ARID domain-containing protein 1C;Jumonji, AT rich interactive domain 1C (RBP2-like)
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Mouse
- Sf9 Insect Cell
- Mammalian Cell
- HEK293
- Flag
- GST
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KDM5C-45H |
Active Recombinant Human KDM5C, FLAG-tagged
|
Sf9 Insect Cell | Human | Flag |
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| KDM5C-1604H | Recombinant Human Lysine (K)-Specific Demethylase 5C, GST-tagged | Sf9 Insect Cell | Human | GST | 1-671 a.a. |
|
| KDM5C-2383R | Recombinant Rhesus monkey KDM5C Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
|
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| KDM5C-6642Z | Recombinant Zebrafish KDM5C | Mammalian Cell | Zebrafish | His |
|
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| KDM5C-7032H | Recombinant Human KDM5C, GST-tagged | Sf9 Insect Cell | Human | GST | 1-671 aa |
|
| KDM5C-8596M | Recombinant Mouse KDM5C Protein | Mammalian Cell | Mouse | His |
|
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| KDM5C-2204R | Recombinant Rhesus Macaque KDM5C Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| KDM5C-2204R-B | Recombinant Rhesus Macaque KDM5C Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| KDM5C-4784M | Recombinant Mouse KDM5C Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| KDM5C-4784M-B | Recombinant Mouse KDM5C Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
KDM5C involved in several pathways and played different roles in them. We selected most pathways KDM5C participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM5C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | ZZZ3,KDM2AA,RUVBL2,SAP130,KDM5D,CAPNS2,MCRS1,RBBP4,MSL1A,MSL2A |
| Chromatin organization | ING4,PADI1,ING5A,RBB4L,PRMT7,HMG20B,MORF4L1,KANSL2,MBD3B,RBBP7 |
| HDMs demethylate histones | PHF2,KDM7AB,KDM4C,JHDM1D,KDM6B,KDM4B,KDM4D,KDM5A,KDM5BA,KDM2B |
Protein Function
KDM5C has several biochemical functions, for example, DNA binding,histone demethylase activity (H3-K4 specific),oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM5C itself. We selected most functions KDM5C had, and list some proteins which have the same functions with KDM5C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | TYW5,ALKBH8,ALKBH5,KDM5D,KDM5BA,KDM5A,EGLN3,C14orf169,PHF8,P4HTM |
| zinc ion binding | ZNF2,ZNF385A,ASTL,TRIM10,ZSWIM2,KDM4B,SIRT5,PRKCG,RNF113A,TRIM23 |
| histone demethylase activity (H3-K4 specific) | KDM5B,KDM1A,KDM5D,C14orf169 |
| DNA binding | WDHD1,Rhox5,ZBTB25,GBX1,HOXD12,TMEM18,HOXB13A,STRBP,FUZ,FOXO3A |
Interacting Protein
KDM5C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM5C here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM5C.
h31_bovin;zipA;ptsN1;CSNK2A1;XPO1;E2F6;TOX4;VPS41;MAX;CSNK2B;SET;MGA;ZNF687;ZNF592;CENPK;TSPYL2;SLC25A22;ZNF532;MBD2;ZMYND8
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